Intravenous infusion of endothelin-1 during prolonged exercise significantly reduced splanchnic blood flow (P<0.001) and splanchnic glucose production by approximately 25% (P<0.01).
Does intravenous endothelin-1 alter splanchnic blood flow and glucose metabolism during moderately heavy prolonged exercise in healthy subjects?
Circulating endothelin-1 exerts a regulatory action on splanchnic blood flow and glucose metabolism during prolonged exercise in healthy humans.
p-value: p=< 0.001
The aims were to investigate 1) the effects of endothelin-1 (ET-1) during exercise and 2) the influence of exercise on arterial ET-1 levels. Six healthy subjects performed two exercises of 2 h duration at 50% of peak oxygen uptake preceded by intravenous infusion of physiological saline or ET-1 (4 pmol.kg-1.min-1). Blood specimens were taken from arterial and hepatic vein catheters. Arterial ET-1 rose 15-fold during the infusion. Splanchnic blood flow fell after ET-1 and remained lower than in control subjects during exercise (P < 0.001). Splanchnic glucose production was approximately 25% lower compared with control values during the whole exercise period (P < 0.01). Neither heart rate, arterial glucagon, insulin, catecholamines, renin, glucose, lactate, nor glycerol levels differed from control exercise values. The calculated gluconeogenesis from glycerol and lactate did not differ from the control values. ET-1 levels rose approximately twofold in the control exercise (P < 0.01) and in another group of seven subjects performing 1 h of exercise at 70% of peak oxygen uptake (P < 0.001). In conclusion, ET-1 levels increased during exercise without ET-1 administration. In addition, circulating ET-1 has a (direct or indirect) regulatory action on splanchnic blood flow and glucose metabolism during exercise (and possibly under pathophysiological conditions) in humans.
Ahlborg et al. (1995) studied Healthy (n=13). Endothelin-1 (ET-1) vs. Physiological saline was evaluated on Splanchnic blood flow and splanchnic glucose production (p=< 0.001). Intravenous infusion of endothelin-1 during prolonged exercise significantly reduced splanchnic blood flow (P<0.001) and splanchnic glucose production by approximately 25% (P<0.01).