Design
Review
Key result
Women experience more serious adverse reactions to therapeutic drugs than men, including a higher risk of drug-induced torsades de pointes due to differences in cardiac repolarization.
Authors
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May warrant closer monitoring for QT prolongation in women; leaves open optimal sex-specific dosing and trial designs.
Margaret A. Miller (2001) conducted a review in Adverse drug reactions. Therapeutic drugs vs. Men was evaluated on Adverse events. Women experience more serious adverse reactions to therapeutic drugs than men, including a higher risk of drug-induced torsades de pointes due to differences in cardiac repolarization.