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May 1, 2001International Journal of Toxicology153 citationsOpen Access

Gender-Based Differences in the Toxicity of Pharmaceuticals—The Food and Drug Administration's Perspective

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Design

Review

Key result

Women experience more serious adverse reactions to therapeutic drugs than men, including a higher risk of drug-induced torsades de pointes due to differences in cardiac repolarization.

Authors

MMMargaret A. Miller

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Overview

May warrant closer monitoring for QT prolongation in women; leaves open optimal sex-specific dosing and trial designs.

PICO

P
Population
Adverse drug reactions
E
Exposure / Comparator
Therapeutic drugs vs Men
O
Primary Outcome
Adverse events
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Margaret A. Miller (2001) conducted a review in Adverse drug reactions. Therapeutic drugs vs. Men was evaluated on Adverse events. Women experience more serious adverse reactions to therapeutic drugs than men, including a higher risk of drug-induced torsades de pointes due to differences in cardiac repolarization.

synapsesocial.com/papers/6aa02760dd133cd5dbe624efhttps://doi.org/10.1080/109158101317097728
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