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September 10, 2026European Journal of Preventive Cardiology0 citationsOpen Access

Self-monitoring patterns after acute coronary syndrome: behavioural markers for secondary prevention

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WLWouter van der LooLeiden University Medical CenterTBTim J. van den BroekNetherlands Organisation for Applied Scientific ResearchSHSara M. HondmannLeiden University

Key Result

Implementation of Medical Service Centre-supported care significantly shifted remote monitoring adherence patterns toward more loyally persisting patients after acute coronary syndrome (p < 0.001).

Key Points

  • To determine whether remote self-monitoring adherence patterns reproduce in a large cohort and assess how clinic outreach and distinct adherence behaviors relate to secondary prevention outcomes.
  • Retrospective cohort study analyzing N=1181 patients enrolled in a 12-month remote monitoring programme after acute coronary syndrome at a tertiary centre.
  • Weekly utilization data from three home-monitoring devices were clustered using time-series k-means algorithms before and after implementation of Medical Service Centre outreach.
  • Changes in blood pressure, lipid profiles, body mass index, risk-factor target attainment, and clinical event rates were evaluated using generalized estimating equations.
  • Time-series analysis replicated three distinct adherence patterns: loyally persisting, temporarily persistent, and negligent quitting.
  • Implementation of Medical Service Centre outreach significantly shifted the patient distribution toward favorable adherence, increasing loyally persisting participation (p < 0.001).
  • Loyally persisting patients demonstrated significantly superior cardiometabolic trajectories, including greater improvements over time in body mass index, triglycerides, and LDL-C target attainment, without significant differences in clinical event rates.

Study Design

Type

Cohort (n=1,181)

Multicenter

No

Structured PICO

Does healthcare worker outreach for missing measurements improve adherence patterns and cardiometabolic profiles in patients undergoing remote monitoring after acute coronary syndrome?

P
Population
1181 patients enrolled in a post-acute coronary syndrome remote monitoring programme at a tertiary centre, monitored over 12 months.
E
Exposure
Healthcare worker outreach triggered by missing measurements (Medical Service Centre, MSC-supported care)
C
Comparator
Remote monitoring before implementation of MSC-supported care
O
Outcome
Adherence patterns, cardiometabolic profiles (blood pressure, lipids, BMI, target attainment), and clinical eventssurrogate

Healthcare worker outreach for missing remote monitoring measurements after ACS improves patient adherence patterns, which is associated with better cardiometabolic risk factor control.

Main Result

p-value: p=<0.001

Abstract

Abstract Background Sustained engagement is essential for remote monitoring (RM) after acute coronary syndrome (ACS), yet self-monitoring behaviour differs across patients and may influence risk-factor control and clinical outcomes. Objectives To assess whether previously identified adherence patterns could be reproduced in a larger cohort, whether healthcare worker outreach triggered by missing measurements (Medical Service Centre, MSC) was associated with more sustained adherence, and whether these patterns were associated with differences in secondary-prevention outcomes and clinical events. Methods In this retrospective cohort study, patients enrolled in a post-ACS RM programme at a tertiary centre were included. Weekly use of three home-monitoring devices over 12 months was grouped into adherence patterns using time-series k-means clustering. Patients were categorised by enrolment before or after implementation of MSC-supported care. Blood pressure, lipids, body mass index (BMI), target attainment and clinical events were analysed using generalized estimating equations. Results A total of 1181 patients were included. Three adherence patterns were identified and replicated, consistent with the patterns previously described as “loyally persisting”,” “temporarily persistent,” and “negligent quitting”. After MSC implementation, the distribution shifted toward more favourable patterns, with more loyally persisting patients (p < 0.001). This pattern showed more favourable cardiometabolic profiles and, for BMI, triglycerides and LDL-C target attainment greater improvement over time. Clinical event rates did not differ significantly between patterns, although directional trends favoured the loyally persisting pattern. Conclusions RM adherence patterns are reproducible and clinically meaningful after ACS, with potential value as behavioural markers for risk stratification and targeted support in secondary prevention.

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Cite This Study

Loo et al. (2026) conducted a cohort in Acute coronary syndrome (n=1,181). Medical Service Centre (MSC)-supported care vs. Care before MSC implementation was evaluated on Shift in adherence patterns (loyally persisting, temporarily persistent, negligent quitting) (p=<0.001). Implementation of Medical Service Centre-supported care significantly shifted remote monitoring adherence patterns toward more loyally persisting patients after acute coronary syndrome (p < 0.001).

synapsesocial.com/papers/6aa27ba958559d80afc74fdfhttps://doi.org/10.1093/eurjpc/zwag486
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