Higher relative abundance of Akkermansia in the gut microbiota was associated with a lower risk of altered cardiovascular risk factors in children with obesity (OR 0.86; 95% CI 0.75-0.97; p=0.033).
Cross-Sectional (n=191)
Lower proportions of Christensenellaceae and Akkermansia and lower diversity are associated with a metabolically unhealthy status in children with obesity.
Odds Ratio: 0.86 (95% CI 0.75–0.97)
p-value: p=0.033
BACKGROUND AND AIMS: We aimed to describe and characterize the gut microbiota composition and diversity in children with obesity according to their metabolic health status. METHODS: Anthropometry, Triglycerides, HDL cholesterol, HOMA-IR, and systolic and diastolic blood pressure (SBP, DBP) were evaluated (and z-score calculated) and faecal samples were collected from 191 children with obesity aged from 8 to 14. All children were classified depending on their cardiometabolic status in either a "metabolically healthy" (MHO; n = 106) or "metabolically unhealthy" (MUO; n = 85) group. Differences in gut microbiota taxonomies and diversity between groups (MUO vs MHO) were analysed. Alpha diversity index was calculated as Chao1 and Simpson's index, and β-diversity was calculated as Adonis Bray-Curtis index. Spearman's correlations and logistic regressions were performed to study the association between cardiometabolic health and the microbiota. RESULTS: = 0.006; p = 0.155). The MUO group was characterized by lower relative abundances of the genera Christensenellaceae R7 group (MHO:1.42% 0.21-2.94; MUO:0.47% 0.02-1.60, p < 0.004), and Akkermansia (MHO:0.26% 0.01-2.19; MUO:0.01% 0.00-0.36, p < 0.001) and higher relative abundances of Bacteroides (MHO:10.6% 4.64-18.5; MUO:17.0% 7.18-27.4, p = 0.012) genus. After the adjustment by sex, age, and BMI, higher Akkermansia (OR: 0.86, CI: 0.75-0.97; p = 0.033), Christensenellaceae R7 group (OR: 0.86, 95% CI: 075-0.98; p = 0.031) and Chao1 index (OR: 0.86, CI: 0.96-1.00; p = 0.023) represented a lower risk of the presence of one or more altered cardiovascular risk factors. CONCLUSION: Lower proportions of Christensenellaceae and Akkermansia and lower diversity and richness seem to be indicators of a metabolic unhealthy status in children with obesity.
Alcázar et al. (2022) conducted a cross-sectional in Obesity (n=191). Higher relative abundance of Akkermansia vs. Lower relative abundance was evaluated on Presence of one or more altered cardiovascular risk factors (OR 0.86, 95% CI 0.75-0.97, p=0.033). Higher relative abundance of Akkermansia in the gut microbiota was associated with a lower risk of altered cardiovascular risk factors in children with obesity (OR 0.86; 95% CI 0.75-0.97; p=0.033).