Online multimodal personalized teleprehabilitation reduced major adverse cardiovascular events at 1 year postoperatively compared to control (16.8% vs 25.5%; difference 8.8%, 95% CI 0.7-16.8; P=0.032).
RCT (n=394)
Blinded event committee
Randomized
Yes
Does an online multimodal personalized teleprehabilitation program reduce major adverse cardiovascular events in patients awaiting elective cardiac surgery and procedures?
Multimodal personalized teleprehabilitation significantly reduced the 1-year incidence of major adverse cardiovascular events in patients undergoing elective cardiac surgery.
Absolute Risk Reduction: 8.8 (95% CI 0.7–16.8)
Absolute Event Rate: 16.8% vs 25.5%
Absolute Risk Reduction: 8.8%
p-value: p=0.032
BACKGROUND: Patients scheduled for cardiac surgery and procedures often present with modifiable risk factors for adverse perioperative outcomes. Prehabilitation has shown potential to enhance mental and physical fitness; however, its effect on clinical cardiovascular endpoints in this population has not been studied. OBJECTIVES: The current trial was designed to evaluate the effect of a personalized multimodal teleprehabilitation on the incidence of composite endpoint on major adverse cardiovascular events in patients scheduled for elective cardiac surgery. METHODS: In a multicenter randomized controlled trial, 394 patients awaiting elective cardiac surgery and procedures were enrolled. Of these, 197 patients were randomized to an online multimodal personalized teleprehabilitation program through shared decision-making by a multidisciplinary team, and 197 were assigned to a control group. The primary outcome was major adverse cardiovascular events (ie, cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure or other life-threatening cardiac events, and earlier or repeated intervention), as measured from the randomization until 1-year postoperatively. All events were adjudicated by a blinded event committee. Secondary outcomes included length of hospital stay, postoperative complications, quality of life, adherence to the program, and effect on the incidence of modifiable risk factors. Sensitivity analyses of the primary outcome were conducted adjusting for baseline characteristics to evaluate the consistency of treatment effects. RESULTS: From randomization until 1 year postoperatively, the primary endpoint occurred in 33 patients (16.8%) in the teleprehabilitation group and 50 patients (25.5%) in the control group (difference 8.8%; 95% CI: 0.7%-16.8%; P = 0.032). This difference was primarily driven by a reduction in hospitalizations, and the sensitivity analyses showed that treatment effect was mainly in the patients undergoing a cardiac surgery rather than transcatheter procedures with adjusted OR of 0.54 (95% CI: 0.30-0.96; P = 0.035). Teleprehabilitation also reduced the incidence of active smokers, elevated pulmonary risk scores, and elevated depression scores. There was no significant difference in postoperative length of hospital stay, occurrence of postoperative complications, physical fitness, incidence of obesity, or malnutrition. CONCLUSIONS: Multimodal personalized teleprehabilitation resulted in a clinically relevant and statistically significant reduction of the primary endpoint in patients undergoing cardiac surgery. (Digital Cardiac Counseling Trial: DCC Trial DCC; NCT04393636).
Scheenstra et al. (2024) conducted an RCT in Elective cardiac surgery and procedures (n=394). Online multimodal personalized teleprehabilitation vs. Control group was evaluated on Major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure or other life-threatening cardiac events, and earlier or repeated intervention) (Difference 8.8%, 95% CI 0.7-16.8, p=0.032). Online multimodal personalized teleprehabilitation reduced major adverse cardiovascular events at 1 year postoperatively compared to control (16.8% vs 25.5%; difference 8.8%, 95% CI 0.7-16.8; P=0.032).