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AHA Scientific Sessions 2026 / Results

AHA Scientific Sessions 2026 Late-Breaking Science Results

Key results for all 22 Late-Breaking Science presentations at AHA Scientific Sessions 2026 in Chicago (November 7-9, 2026), grouped by session. Each trial links to the full Synapse analysis with PICO breakdown, expert commentary, and the simultaneous journal publication where available.

Last updated 2026-10-23

Late-Breaking Science 1 — Prevention lessons from landmark trials

Saturday, November 7 · 08:30 - 09:45 CT

ZEUS: Primary report of the ziltivekimab cardiovascular outcomes trial (ZEUS)

Results live Saturday in Chicago.

Presented by Paul Ridker, Mass General Brigham Hospital, Boston, USA · Prevention · Full analysis

Lp(a)HORIZON: Effect of pelacarsen on cardiovascular outcomes in patients with elevated lipoprotein(a): primary results from the Lp(a)HORIZON trial

Results live Saturday in Chicago.

Presented by Steven Nissen, C5Research at Cleveland Clinic, Cleveland, USA · Lipids · Full analysis

Lp(a)HORIZON Extended Analyses: Extended analyses of cardiovascular outcomes with pelacarsen treatment in the Lp(a)HORIZON trial

Results live Saturday in Chicago.

Presented by Steven Nissen, Cleveland Clinic Foundation, Cleveland, USA · Lipids · Full analysis

Late-Breaking Science 2 — Improving outcomes after stroke

Saturday, November 7 · 13:45 - 14:45 CT

OCEANIC-STROKE: FXIa inhibition by asundexian in participants with non-cardioembolic stroke or transient ischemic attack by non-laboratory Framingham risk score category: outcomes in the OCEANIC-STROKE randomized, placebo-controlled trial

Results live Saturday in Chicago.

Presented by Mukul Sharma, Population Health Research Institute, McMaster University, Hamilton, Canada · Stroke · Full analysis

REDUCE: A randomized controlled trial of spironolactone-based blood pressure management after stroke (REDUCE)

Results live Saturday in Chicago.

Presented by Jordana Cohen, University of Pennsylvania, Philadelphia, USA · Stroke · Full analysis

OPTIMAL-Stroke: Intensive blood-pressure control for the prevention of major cardiovascular events in patients with prior stroke: the OPTIMAL-Stroke trial

Results live Saturday in Chicago.

Presented by Gisele Sampaio, Hospital Israelita Albert Einstein and Universidade Federal de São Paulo, São Paulo, Brazil · Stroke · Full analysis

Late-Breaking Science 3 — Hot topics in CVD prevention

Saturday, November 7 · 15:15 - 16:30 CT

STREAM: Discontinuing statins in multimorbid older adults without cardiovascular disease: a randomized non-inferiority clinical trial (STREAM)

Results live Saturday in Chicago.

Presented by Nicolas Rodondi, Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland · Prevention · Full analysis

OPTIMAL-DIABETES: Intensive blood pressure control for the prevention of major cardiovascular events in patients with type 2 diabetes: the OPTIMAL-DIABETES trial

Results live Saturday in Chicago.

Presented by Karla Santo, Hospital Israelita Albert Einstein, São Paulo, Brazil · Hypertension · Full analysis

eZ-PAVE: Statin-ezetimibe combination therapy versus statin monotherapy in patients with atherosclerotic cardiovascular disease: pre-specified second randomization of the eZ-PAVE trial

Results live Saturday in Chicago.

Presented by Byeong-Keuk Kim, Yonsei University Severance Hospital, Seoul, Republic of Korea · Lipids · Full analysis

Yoga-CaRe HF: Yoga-based cardiac rehabilitation in heart failure with reduced ejection fraction (Yoga-CaRe HF)

Results live Saturday in Chicago.

Presented by Dorairaj Prabhakaran, Centre for Chronic Disease Control, New Delhi, India · Heart Failure · Full analysis

Late-Breaking Science 4 — Innovations to optimize arrhythmia care

Sunday, November 8 · 15:30 - 16:45 CT

OptimPacing: Left bundle branch pacing versus right ventricular pacing for atrioventricular block: an international multi-center randomized controlled trial (OptimPacing)

Results live Sunday in Chicago.

Presented by Jiangang Zou, First Affiliated Hospital of Nanjing Medical University, Nanjing, China · Devices & Arrhythmias · Full analysis

COAST-AF Randomized: Characterization of arrhythmia substrate to ablate persistent atrial fibrillation: the COAST-AF randomized trial

Results live Sunday in Chicago.

Presented by Pablo Nery, University of Ottawa Heart Institute, Ottawa, Canada · Atrial Fibrillation · Full analysis

SUPERIOR: Sacubitril/valsartan for preventing recurrence of atrial fibrillation after catheter ablation in patients with hypertension: a multicenter, randomized controlled trial (SUPERIOR)

Results live Sunday in Chicago.

Presented by Wei Zhang, Shanghai Institute of Hypertension, Shanghai, China · Atrial Fibrillation · Full analysis

RACE-CARS: Randomized cluster evaluation of cardiac arrest systems (RACE-CARS) trial: primary results

Results live Sunday in Chicago.

Presented by Carolina Malta Hansen, Copenhagen EMS, Ballerup, Denmark · Acute Cardiac Care · Full analysis

Late-Breaking Science 5 — New frontiers in cardiometabolic risk reduction

Monday, November 9 · 08:00 - 09:15 CT

TYDAL-TIMI 78: A randomized trial of ANGPTL4 inhibition with MAR001 in adults with elevated triglycerides and remnant cholesterol concentrations (TYDAL-TIMI 78)

Results live Monday in Chicago.

Presented by Michelle O'Donoghue, Brigham and Women's Hospital, Boston, USA · Lipids · Full analysis

CTX310: CRISPR-Cas9 gene editing therapy targeting ANGPTL3 for severe hypertriglyceridemia: results from a phase 1b trial (CTX310)

Results live Monday in Chicago.

Presented by Ashish Sarraju, Cleveland Clinic, Cleveland, USA · Lipids · Full analysis

ATTAIN-OSA: Orforglipron for the treatment of obstructive sleep apnea: results from ATTAIN-OSA

Results live Monday in Chicago.

Presented by Vaishnavi Kundel, Icahn School of Medicine at Mount Sinai, New York, USA · Cardiometabolic · Full analysis

SYNCHRONIZE-CVOT: Survodutide and cardiovascular outcomes in obesity: results from the SYNCHRONIZE-CVOT trial

Results live Monday in Chicago.

Presented by Biykem Bozkurt, Baylor College of Medicine, Houston, USA · Cardiometabolic · Full analysis

Late-Breaking Science 6 — AI in the diagnosis of cardiovascular disease

Monday, November 9 · 09:45 - 11:00 CT

WATCH-LV: Consumer smartwatch artificial intelligence-enabled electrocardiogram for left ventricular systolic dysfunction: cross-manufacturer validation and serial home monitoring (WATCH-LV)

Results live Monday in Chicago.

Presented by Hak Seung Lee, Sejong Medical Research Institute, Bucheon, Republic of Korea · Digital Health · Full analysis

PROVAR+: AI-enabled tele-ECG identifies structural heart disease and prioritizes echocardiography in underserved populations: the PROVAR+ external validation study

Results live Monday in Chicago.

Presented by Bruno Nascimento, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil · Digital Health · Full analysis

AI-Echo RCT: AI-assisted comprehensive echocardiographic interpretation: a blinded, randomized controlled trial

Results live Monday in Chicago.

Presented by Keane Lee, Kaiser Permanente, Santa Clara, USA · Imaging · Full analysis

AI Plaque + FFR-CT: All-cause and cardiovascular mortality in the U.S.: risk stratification via integrated AI-enabled coronary plaque analysis and FFR-CT in over 269,000 patients (LIFE-AI Study)

Results live Monday in Chicago.

Presented by Ankitkumar Patel, Hackensack Meridian Health, Glen Ridge, USA · Imaging · Full analysis

Follow the discussion, expert commentary, and PICO analysis for every trial on the AHA Scientific Sessions 2026 hub.

Cite this page: "AHA Scientific Sessions 2026 Late-Breaking Science Results, Synapse (synapsesocial.com), https://synapsesocial.com/aha/results."