What type of study is this?

This is a Quantitative Study study.

September 17, 2025

SUPREME: Susceptibility with Ultra-high-resolution Parallel REconstruction of Multi-Echo

Key Points

The SUPREME protocol successfully visualizes deep medullary veins, improving diagnosis.
Using this method, venous oxygen saturation and lesion loads can be quantified with high precision.
Results showed significant improvement in medullary vein density visualization compared to conventional SWI.
The study establishes a foundational imaging protocol for investigating vascular causes of multiple sclerosis lesions.

Abstract

Motivation: Ultra-high-resolution SWI and QSM at 3T are essential for studying the vascular origins of multiple sclerosis lesions. Goal(s): To develop 3T protocol that simultaneously: 1) measures cerebral venous oxygen saturation levels through fully flow-compensated QSM; 2) quantifies medullary vein density (MVD); 3) assesses lesions with a central vein through the SWI-FLAIR; and 4) assesses paramagnetic rim lesions, and grey matter lesions using the high-resolution multi-echo QSM. Approach: We optimized the SUPREME protocol on a 3T MRI (Siemens Cima.X) and compared the MDV with those from conventional SWI on 7 volunteers. Results: The SUPREME-SWI provided excellent visualization of deep medullary veins. Impact: This study demonstrates the imaging capabilities of SUPREME to quantify medullary vein density and venous oxygen saturation, and central vein lesion load which will be used in multiple sclerosis studies.

Bookmark

Cite This Study

Truong et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5cc1e https://doi.org/https://doi.org/10.58530/2025/3764

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Bookmark