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August 13, 2002Circulation323 citations

Low-Output, Low-Gradient Aortic Stenosis in Patients With Depressed Left Ventricular Systolic Function

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RNRick A. NishimuraJGJ. Aaron GranthamHCHeidi M. Connolly

Structured PICO

Does dobutamine challenge aid in selecting patients with low-output, low-gradient aortic stenosis and depressed left ventricular systolic function who would benefit from an aortic valve operation?

P
Population
Patients with left ventricular systolic dysfunction and aortic stenosis with a low output and a low mean gradient
I
Intervention
Dobutamine challenge
O
Outcome
Selection of patients who would benefit from an aortic valve operation

Dobutamine challenge may help identify patients with low-output, low-gradient aortic stenosis and LV dysfunction who will benefit from aortic valve surgery.

Abstract

In patients with left ventricular systolic dysfunction and aortic stenosis with a low output and a low mean gradient, dobutamine challenge may aid in selecting those who would benefit from an aortic valve operation.

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Cite This Study

Nishimura et al. (2002) studied this question.

synapsesocial.com/papers/69effb5c4f6a06657c21e3e3https://doi.org/10.1161/01.cir.0000025611.21140.34
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aortic stenosis with severe left ventricular dysfunction and low transvalvular pressure gradients2001 · 264 citations
  2. 2Dobutamine Echocardiography in Patients With Aortic Stenosis and Left Ventricular Dysfunction2001 · 102 citations
  3. 3Usefulness of dobutamine echocardiography in distinguishing severe from nonsevere valvular aortic stenosis in patients with depressed left ventricular function and low transvalvular gradients1995 · 367 citations
  4. 4Aortic valve resistance as an adjunct to the gorlin formula in assessing the severity of aortic stenosis in symptomatic patients1992 · 132 citations
  5. 5Afterload mismatch and preload reserve: A conceptual framework for the analysis of ventricular function1976 · 655 citations