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December 1, 1995Circulation Research

Renal Effects of High-Dose Natriuretic Peptide Receptor Blockade in Rats With Congestive Heart Failure

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Why the study?

Does natriuretic peptide receptor blockade with HS-142-1 alter renal function and hemodynamics in rats with congestive heart failure?

Population

Anesthetized rats subjected to coronary ligation that developed left ventricular infarction and congestive…

Comparison

HS-142-1, a potent natriuretic peptide receptor… vs Sham-operated control rats receiving the same…

Design

Preclinical

Key result

Administration of the natriuretic peptide receptor antagonist HS-142-1 significantly reduced glomerular filtration rate (1.26 to 0.76 mL/min) and renal plasma flow in rats with congestive heart failure.

Authors

PZPing L. ZhangHMHarald S. MackenzieKTKazuhito Totsune

Discussion

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Overview

Highlights endogenous natriuretic peptides' renal protective role in experimental heart failure; leaves open human therapeutic relevance.

Structured PICO

Does natriuretic peptide receptor blockade with HS-142-1 alter renal function and hemodynamics in rats with congestive heart failure?

P
Population
Anesthetized rats subjected to coronary ligation that developed left ventricular infarction and congestive heart failure (CHF), and sham-operated (SO) control rats
I
Intervention
HS-142-1 (HS), a potent natriuretic peptide receptor antagonist, administered as a 20 mg/kg IV bolus
C
Comparator
Sham-operated (SO) control rats receiving the same intervention, and baseline pre-intervention values
O
Outcome
Renal responses including glomerular filtration rate (GFR), renal plasma flow rate (RPF), sodium excretion rate, and fractional sodium excretionsurrogate

Natriuretic peptides play a critical role in maintaining renal hemodynamic function and inhibiting tubule sodium reabsorption in rats with congestive heart failure, opposing sodium retention.

Cite This Study

Zhang et al. (1995) studied Congestive heart failure (in rats). HS-142-1 (NP receptor antagonist) vs. Sham-operated control rats was evaluated on Glomerular filtration rate (GFR) and renal plasma flow rate (RPF). Administration of the natriuretic peptide receptor antagonist HS-142-1 significantly reduced glomerular filtration rate (1.26 to 0.76 mL/min) and renal plasma flow in rats with congestive heart failure.

synapsesocial.com/papers/6a11777e65e578e483594299https://doi.org/10.1161/01.res.77.6.1240
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of endogenous atrial natriuretic peptide on systemic and renal hemodynamics in heart failure rats1994 · 27 citations
  2. 2Renal Function in High-Output Heart Failure in Rats1999 · 7 citations
  3. 3Short-Term and Long-Term Inhibition of Endogenous Atrial Natriuretic Peptide in Dogs With Early-Stage Heart Failure1998 · 11 citations
  4. 4Increased Plasma Levels and Blunted Effects of Brain Natriuretic Peptide in Rats With Congestive Heart Failure1991 · 24 citations
  5. 5Atrial Natriuretic Peptide (ANP) Inhibits Its Own Secretion via ANPA Receptors: Altered Effect in Experimental Hypertension*1997 · 14 citations