Screening and mechanism validation of anti-ulcerative colitis medicinal couplet in Chinese herbal medicine based on data mining technology

Key Points

• The aim is to explore the potential of anti-aging herbal medicine in treating ulcerative colitis (UC) and provide a reference for innovative herbal development.
• Analyzed usage patterns of anti-aging herbs using data mining techniques.
• Constructed a UC mouse model with dextran sulfate sodium and evaluated treatment effects by qRT-PCR to assess inflammatory factors.
• Selected high-frequency herbal pairs from traditional texts based on inclusion and exclusion criteria.
• Identified 101 oral formulations incorporating 129 herbs, with ginseng and poria ranking highest.
• In UC mice, treatment showed significant efficacy with a decrease in Disease Activity Index (DAI) P<0.01.
• Notable improvements in colon length P<0.001 and significant reductions in inflammatory factors IL-1β and IL-6 P<0.01.