Screening and mechanism validation of anti-ulcerative colitis medicinal couplet in Chinese herbal medicine based on data mining technology

September 1, 2025Lishizhen medicine and materia medica research

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Key Points

The aim is to explore the potential of anti-aging herbal medicine in treating ulcerative colitis (UC) and provide a reference for innovative herbal development.
Analyzed usage patterns of anti-aging herbs using data mining techniques.
Constructed a UC mouse model with dextran sulfate sodium and evaluated treatment effects by qRT-PCR to assess inflammatory factors.
Selected high-frequency herbal pairs from traditional texts based on inclusion and exclusion criteria.
Identified 101 oral formulations incorporating 129 herbs, with ginseng and poria ranking highest.
In UC mice, treatment showed significant efficacy with a decrease in Disease Activity Index (DAI) P<0.01.
Notable improvements in colon length P<0.001 and significant reductions in inflammatory factors IL-1β and IL-6 P<0.01.

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Finds significant effects of ginseng and poria in mouse models of ulcerative colitis, suggesting new treatment options.

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ZHENG et al. (2025) studied this question.

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