Exploring the prescription principles and mechanisms of TCM compound prescription for treating hyperuricemia based on data mining and experimental validation

June 1, 2026Lishizhen medicine and materia medica research

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Key Points

The aim is to systematically identify TCM compound prescriptions for hyperuricemia and validate their mechanisms through animal tests.
Utilized a database to screen patents for hyperuricemia treatment, identifying 171 compounds.
Analyzed data using statistical methods and clustering to select core prescriptions.
Conducted experiments on a rat model to measure uric acid levels and assess protein expression related to kidney function.
Core prescription significantly reduced serum uric acid, creatinine, and urea nitrogen levels (P<0.05).
Improved kidney pathology, including reduced vacuolization and fibrosis (P<0.05).
Regulated the expression of uric acid transport proteins, enhancing uric acid excretion while reducing injury markers (P<0.05).

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Investigates TCM compound's effects on hyperuricemia, showing multi-target kidney protection and uric acid reduction.

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YANG et al. (2026) studied this question.

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