Yiannis S. Chatzizisis works in Interventional Cardiology affiliated with University of Miami.
Yiannis S. Chatzizisis is Professor of Cardiology and Chief of the Cardiovascular Division at the University of Miami Miller School of Medicine. He previously held positions as Professor of Medicine and Chief of Interventional Cardiology at the University of Nebraska Medical Center. His research focuses on the role of endothelial shear stress in coronary atherosclerosis and the development of high-risk plaques.
Research focus
Coronary Bifurcation InterventionsEndothelial Shear Stress in AtherosclerosisIntravascular ImagingVascular RemodelingStent Restenosis and Thrombosis
Impact
184 pubs · 6,100 cites · h-index 34
Training
MD
Aristotle University of Thessaloniki School of Medicine
2000
MSc
Aristotle University Medical School
2004
PhD
Aristotle University Medical School
2009
Affiliations
Work Experience
Professor and Chief, Division of Cardiovascular Medicine
University of Miami Miller School of Medicine · 2023 - Present
Professor of Medicine and Chief of Interventional Cardiology
University of Nebraska Medical Center · 2015 - 2023
Interventional Cardiology Fellow
Brigham and Women's Hospital, Harvard Medical School · 2014 - 2015
Advanced Cardiac Imaging Fellow
Brigham and Women's Hospital, Harvard Medical School · 2012 - 2014
Despite advances in vulnerable plaque imaging, its predictive value for clinical events remains limited, prompting investigation into novel pathobiological mechanisms like microcalcifications and biomechanical factors.
Despite advances in vulnerable plaque imaging, its predictive value for clinical events remains limited, prompting investigation into novel pathobiological mechanisms like microcalcifications and biomechanical factors.
PS
Peter H. Stone
Cardiologist, Brigham and Women's Hospital · Brigham and Women's Hospital
“
Low endothelial shear stress at baseline was significantly associated with percent change in maximum plaque thickness at follow-up. ESS is the tangential force derived from the friction of blood flowing across the endothelium. Where laminar flow is disturbed downstream from an obstruction, there is in vivo and ex vivo evidence that local low ESS leads to increased low-density lipoprotein build-up, intense inflammation with accumulation of activated macrophages, increased plaque growth, plaque cap thinning, and excessive expansive remodeling.
Role of Endothelial Shear Stress in Stent Restenosis and Thrombosis
Journal of the American College of Cardiology · Koskinas et al. ·
review3 mentionsJACC Highlight
JUN 2007ChatzizisisJournal of the American College of Cardiology
Triple M overlap syndrome is a severe, life-threatening immune-related adverse event of immune checkpoint inhibitors that presents with myocarditis, myositis, and myasthenia gravis, requiring aggressive immunomodulatory therapy beyond corticosteroids.
Triple M overlap syndrome is a severe, life-threatening immune-related adverse event of immune checkpoint inhibitors that presents with myocarditis, myositis, and myasthenia gravis, requiring aggressive immunomodulatory therapy beyond corticosteroids.
Yiannis S. Chatzizisis
Interventional cardiologist, institution not specified
“
In an era dominated by artificial intelligence, the trial provides meaningful support for a less-invasive physiology-guided strategy that may simplify decision making in treating the majority of patients with stable or unstable intermediate coronary lesions.
Redefining Physiology in the Cardiac Catheterization Laboratory
New England Journal of Medicine · Chatzizisis ·
cohort · n=933
FEB 1ElbenawiJournal of the Society for Cardiovascular Angiography & Interventions
A high-fidelity full-plaque computational model accurately simulates coronary bifurcation stenting and biomechanical behavior, showing strong agreement with post-stenting OCT.
A high-fidelity full-plaque computational model accurately simulates coronary bifurcation stenting and biomechanical behavior, showing strong agreement with post-stenting OCT.
Background: Hypertension remains a leading cause of cardiovascular morbidity and mortality, disproportionately affecting low- and middle-income countries (LMICs), where healthcare access and awareness are limited. Excessive sodium intake, often from discretionary salt used in cooking, contributes significantly to this burden. Salt substitutes, typically formulated by partially replacing sodium chloride with potassium chloride or other minerals, offer a cost-effective dietary intervention to lower blood pressure (BP) and reduce cardiovascular risk, particularly in resource-constrained settings. Objective: This review examines the efficacy of low-sodium salt substitutes (LSSS) in reducing blood pressure (BP) and its effects on cardiovascular (CV) outcomes, safety concerns, and challenges to their implementation in LMICs. Methods: We conducted a comprehensive narrative review of studies published between 1994 and 2024 using PubMed, Embase, and Scopus databases. Eligible studies included randomized controlled trials, systematic reviews, observational studies, and implementation research that evaluated the effects of LSSS on BP, CV outcomes, safety, and feasibility in LMIC contexts. Thematic synthesis was used to summarize the findings. Key Findings: Salt substitutes consistently lowered systolic and diastolic BP across diverse populations, with mean reductions ranging from 3 to 5 mmHg. Trials have also demonstrated reductions in stroke incidence, CV events, and all-cause mortality. However, the benefits were mostly derived from studies conducted in China and other upper-middle-income settings. Safety concerns (particularly hyperkalemia in individuals with chronic kidney disease or RAAS inhibitors) warrant targeted risk screening and public education. Implementation barriers in LMICs include cost, limited availability, poor awareness, and a lack of regulatory oversight. Conclusions: Salt substitutes present a promising, scalable strategy to reduce BP and CV disease burden in LMICs. However, their adoption must be context-specific, culturally sensitive, and supported by government subsidies, regulatory frameworks, and educational campaigns. Future trials should evaluate the long-term safety and cost-effectiveness in underrepresented LMIC populations to guide equitable public health interventions.
Background: Hypertension remains a leading cause of cardiovascular morbidity and mortality, disproportionately affecting low- and middle-income countries (LMICs), where healthcare access and awareness are limited. Excessive sodium intake, often from discretionary salt used in cooking, contributes significantly to this burden. Salt substitutes, typically formulated by partially replacing sodium chloride with potassium chloride or other minerals, offer a cost-effective dietary intervention to lower blood pressure (BP) and reduce cardiovascular risk, particularly in resource-constrained settings. Objective: This review examines the efficacy of low-sodium salt substitutes (LSSS) in reducing blood pressure (BP) and its effects on cardiovascular (CV) outcomes, safety concerns, and challenges to their implementation in LMICs. Methods: We conducted a comprehensive narrative review of studies published between 1994 and 2024 using PubMed, Embase, and Scopus databases. Eligible studies included randomized controlled trials, systematic reviews, observational studies, and implementation research that evaluated the effects of LSSS on BP, CV outcomes, safety, and feasibility in LMIC contexts. Thematic synthesis was used to summarize the findings. Key Findings: Salt substitutes consistently lowered systolic and diastolic BP across diverse populations, with mean reductions ranging from 3 to 5 mmHg. Trials have also demonstrated reductions in stroke incidence, CV events, and all-cause mortality. However, the benefits were mostly derived from studies conducted in China and other upper-middle-income settings. Safety concerns (particularly hyperkalemia in individuals with chronic kidney disease or RAAS inhibitors) warrant targeted risk screening and public education. Implementation barriers in LMICs include cost, limited availability, poor awareness, and a lack of regulatory oversight. Conclusions: Salt substitutes present a promising, scalable strategy to reduce BP and CV disease burden in LMICs. However, their adoption must be context-specific, culturally sensitive, and supported by government subsidies, regulatory frameworks, and educational campaigns. Future trials should evaluate the long-term safety and cost-effectiveness in underrepresented LMIC populations to guide equitable public health interventions.
Computational analysis demonstrates high accuracy in stent deployment outcomes using detailed finite element models, highlighting potential clinical applications.
Computational analysis demonstrates high accuracy in stent deployment outcomes using detailed finite element models, highlighting potential clinical applications.
The latest HD IVUS (Avvigo+) tends to overestimate lumen size, whereas OCT (Ultreon 2.0) underestimates it. Experimental data suggest HD IVUS provides more accurate lumen assessment, particularly in larger coronary arteries, although both technologies exhibit comparable overall accuracy in the clinical setting.
The latest HD IVUS (Avvigo+) tends to overestimate lumen size, whereas OCT (Ultreon 2.0) underestimates it. Experimental data suggest HD IVUS provides more accurate lumen assessment, particularly in larger coronary arteries, although both technologies exhibit comparable overall accuracy in the clinical setting.
AI has the potential to significantly improve preprocedural planning and procedural assistance in coronary interventions, though ethical and transparency challenges remain.
AI has the potential to significantly improve preprocedural planning and procedural assistance in coronary interventions, though ethical and transparency challenges remain.
Case report demonstrates successful percutaneous coil embolization of a traumatic coronary pseudoaneurysm in an older adult, highlighting a viable catheter-based alternative to re-sternotomy.
Case report demonstrates successful percutaneous coil embolization of a traumatic coronary pseudoaneurysm in an older adult, highlighting a viable catheter-based alternative to re-sternotomy.
