Key result
Low endothelial shear stress promotes high-risk coronary plaques via lipid accumulation and excessive expansive remodeling.
Why the study?
The pathophysiologic mechanisms involved in the remodeling of the atherosclerotic wall are incompletely understood, but the interplay between local hemodynamics, low endothelial shear stress, and wall biology is likely important.
Low endothelial shear stress plays a critical role in the progression of coronary atherosclerosis and the development of high-risk plaques through excessive expansive remodeling.
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May support future high-risk plaque identification; leaves open whether shear stress modulation improves outcomes.
Chatzizisis et al. (2007) conducted a review in Coronary atherosclerosis and vascular remodeling. Low endothelial shear stress was evaluated. Low endothelial shear stress promotes the formation and progression of high-risk coronary atherosclerotic plaques through local lipid accumulation and excessive expansive remodeling.
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