Tomasz J. Guzik

Vascular / Pulmonary Vascular

Jagiellonian University

About

Tomasz J. Guzik works in Vascular / Pulmonary Vascular affiliated with Jagiellonian University.

Tomasz J. Guzik is Chair of Cardiovascular Medicine at the University of Edinburgh and Professor of Medicine at Jagiellonian University Collegium Medicum in Kraków. He is Editor-in-Chief of Cardiovascular Research, published by the European Society of Cardiology. His research focuses on inflammation, oxidative stress, and adaptive immunity in hypertension, atherosclerosis, and vascular disease.

Research focus

Vascular oxidative stress and endothelial dysfunctionImmune and inflammatory mechanisms of hypertensionAtherosclerosis and neuroimmune regulationVascular complications of diabetesTranslational cardiovascular immunology

Impact

481 pubs · 36,934 cites · h-index 83

Training

MD
Jagiellonian University Collegium Medicum
1998
PhD
Jagiellonian University Collegium Medicum
2000
Molecular Medicine (postgraduate)
University of Oxford
2004

Affiliations

Work Experience

Chair of Cardiovascular Medicine

University of Edinburgh · 2023 - Present

Professor of Medicine and Head of the Chair and Clinic of Internal Medicine and Agricultural Medicine

Jagiellonian University Collegium Medicum · 2009 - Present

Regius Professor of Physiology and Cardiovascular Medicine

University of Glasgow · 2012 - 2022

Associate Professor

Emory University School of Medicine · 2005 - 2008

Publications

EHJMaffia et al.editorial

The Africa-Europe Cluster of Research Excellence unites 15 African and 4 European partners to build capacity and tackle cardiovascular diseases in Africa, where research accounts for 3% globally.

This Global Spotlight outlines the Africa-Europe Cluster of Research Excellence (CoRE) in Non-Communicable Diseases & Multimorbidity, an international collaborative network of 15 African and 4 European institutions aimed at building research capacity and developing context-specific strategies to combat the rising burden of cardiovascular disease in Africa.

Cardiovascular ResearchZhang et al.preclinical

Endothelial ADRB3 overexpression reduces post-MI fibrosis and improves cardiac function by suppressing EndoMT.

Endothelial ADRB3 may aid post-MI repair in mice; leaves open translation to human cardiac repair.

Cardiovascular ResearchKyslyi et al.Original Research

From one plaque to many: the coming tsunami of pan-vascular disease: bringing pan-vascular disease to the centre of cardiovascular prevention

This Week in General Medicine

Medical News Analysis · YouTube

Inequalities widened at every step of the cascade and were worst at the point of disease control. The regional patterns diverged sharply. In the Americas, control consistently favored wealthier people, whereas in the African region, coverage was uniformly low, and the largest absolute gaps actually favored the least wealthy, particularly for lipid treatment.

Global inequalities in cardiometabolic care and achievable cardiovascular risk reduction by wealth, region, and sex: a pooled analysis of individual participant data from 76 countries

The Lancet Global HealthGaye et al.Sep 2026

EHJHill et al.editorial

Medical misinformation spread through the internet and social media causes significant harm by discouraging the use of life-saving treatments like statins and vaccines.

Editors-in-chief of major cardiovascular journals call on media and social media platforms to take responsibility for vetting medical content to stop the harmful spread of misinformation regarding proven therapies like statins and vaccines.

Circulation ResearchChen et al.preclinical

B1a cell transfer prevents Ang II-induced hypertension and vascular damage by producing natural IgM.

May warrant investigation of B1a cells as a therapeutic target in hypertension; leaves open translation from mouse models to clinical use.

EHJGuzik et al.editorial

Artificial intelligence in biomedical publishing offers opportunities to accelerate knowledge generation but introduces risks requiring transparency, provenance, and enforceable human responsibility.

This commentary highlights the need for transparency, provenance, and enforceable human responsibility to mitigate the risks of AI in biomedical publishing.

John Eikelboom

Cross-Cutting Cardiology · Sigmund Freud Privatuniversität Wien

5mo

The substantial benefits seen with rivaroxaban and aspirin support the approach of using low doses of the 2 treatments in combination.

Mortality Benefit of Rivaroxaban Plus Aspirin in Patients With Chronic Coronary or Peripheral Artery Disease

Journal of the American College of CardiologyEikelboom et al.Jun 2021

ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Antoniades et al.cross-sectional

GCH1 X haplotype is linked to reduced BH4, higher vascular superoxide, and impaired vasorelaxation in CAD.

Genetic variation in the GCH1 gene (X haplotype) significantly impairs endogenous BH4 availability, leading to endothelial dysfunction and increased oxidative stress in patients with coronary artery disease.

EHJHoefer et al.Guideline

Novel methodologies for biomarker discovery in atherosclerosis

This consensus statement outlines the current state and future directions of biomarker research, emphasizing novel -omics technologies for enhanced cardiovascular risk prediction.

Emmett et al.Original Research

Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome

Chronic Kidney Disease (CKD) is a complex polygenic disease. We performed genome-wide association meta-analyses of four CKD-defining traits in up to 890,000 individuals and identified 508 loci associated with at least one trait, including 237 multi-trait CKD loci. Colocalization with kidney mRNAs, proteins and methylation patterns prioritized 651 CKD kidney genes (including 330 novel candidates) at 320 CKD-defining trait loci. We discovered over-representation of CKD kidney genes within multi-trait CKD loci. CKD kidney genes which colocalized with multiple CKD-defining traits exhibited greater relevance to kidney biology, health and disease. We found evidence for genetic regulation of developmental DNA methylation patterns that determine kidney health later in life. Finally, through analysis of Isolated Hyperchlorhidrosis - a rare genetic syndrome associated with Carbonic Anhydrase 12 (a novel CKD kidney gene) - we uncovered new metabolic consequences of genetic CA12 loss (hyperuricemia, reduced kidney function) and illuminated adverse effects of CA12-inhibitors (acetazolamide).

Arteriosclerosis Thrombosis and Vascular BiologyPolkinghorne et al.cohort

High Lp(a) linked to a ~3-fold higher cardiac mortality risk in advanced CAD.

Genetically determined increases in plasma Lp(a) are associated with dysregulated vascular redox signaling and increased cardiac mortality in patients with advanced coronary atherosclerosis.

EHJChiva‐Blanch et al.review

Multidisciplinary education is needed to bridge the gap between discovery science and clinical practice.

Highlights the critical need for integrated education and training programs to bridge the gap between basic discovery science and clinical cardiology.

NEJMGuzik et al.Original Research

Aldosterone Synthase Inhibition for Hypertension

Observational analysis shows aldosterone's impact on blood pressure in resistant hypertension, suggesting new treatment routes.

Cardiovascular ResearchGuzik et al.editorial

The ESC Congress 2025 celebrates the 75th anniversary of the European Society of Cardiology, highlighting upcoming pivotal trials, new guidelines, and a focus on global health and innovation.

The ESC Congress 2025 in Madrid will celebrate the 75th anniversary of the ESC, highlighting global health, interdisciplinary integration, and upcoming pivotal trials and guidelines.

Journal of Clinical InvestigationHennen et al.Original Research

Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models

Analysis shows hypertension reduces bone mineral density in mouse models and humans, suggesting immune involvement in bone health.

Morsy et al.Cohort Study

Inflammatory Markers are Associated with Ischemic Stroke among Indigenous Africans: Evidence from the SIREN Study

Retrospective analysis reveals associations between inflammation and stroke outcomes in indigenous Africans, suggesting new biomarkers for prediction.

ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Olowoyo et al.meta-analysis

The pooled crude prevalence of hypertension was 28.5/100 persons, and the pooled age-standardized prevalence was 27.2/100 persons.

The burden of hypertension in Africa is high, affecting approximately 28.5% of the population, with higher rates in urban areas and older individuals.

Circulation ResearchZiegler et al.review

The review highlights the neurocardiac axis as a critical nexus in heart failure and cardiometabolic disease, and suggests that targeting neurocardiac and neuroimmune pathways offers therapeutic promise.

This review highlights the critical role of the neurocardiac and neuroimmune axes in heart failure and cardiometabolic diseases, suggesting that targeting these pathways may offer new precision therapeutic approaches.

Circulation ResearchPan et al.preclinical

PGC-1α overexpression in aged mice or administration of verteporfin restored PVAT function and conferred protection against AAA formation.

PGC-1α deficiency in SM22α-lineage perivascular stromal cells promotes abdominal aortic aneurysm development, suggesting PGC-1α or YAP signaling as potential therapeutic targets.

All publications →