193 pubs · 4,533 cites · h-index 38
Evaluates a phospholipid-loaded SMEDDS formulation to improve H007 delivery in hamsters, suggesting better therapeutic options.
A two-stage translational study assesses a new suture-augmented prosthesis for stable fixation in osteoporotic hip fractures, suggesting improved outcomes.
Multicenter cohort study reveals optimal surgery timing after immunochemotherapy improves outcomes in lung cancer patients.
Reveals improved mechanical, thermal, and electromagnetic shielding in CFRP composites, indicating an efficient fabrication method.
Investigates fat replacement in sausages using emulsions, suggesting improved quality and sensory attributes.
Innovative robotic platform automates single-cell picking and placement, suggesting improved precision for biomedical applications.
Geostatistical analysis reveals soil C-N-P dynamics in agricultural soils, indicating important management insights.
Prospective study compares acetaminophen and ibuprofen treatments for infants with hsPDA, showing comparable effectiveness and safety.
Targeting the programmed cell death 1 (PD-1)/PD-L1 axis has revolutionized cancer therapy; however, the durability of clinical responses is frequently compromised by chronic inflammation and an immunosuppressive tumor microenvironment (TME). The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway serves as a central intracellular node integrating cytokine signals that drive these resistance mechanisms. While physiological JAK/STAT signaling is essential for antitumor immunity, its persistent aberrant activation promotes malignant progression, upregulates PD-L1 expression, and orchestrates an immunosuppressive landscape by recruiting myeloid-derived suppressor cells (MDSCs) and polarizing tumor-associated macrophages (TAMs) toward an M2 phenotype, ultimately leading to T cell exhaustion. This review comprehensively elucidates the multifaceted role of JAK/STAT signaling in shaping the immune architecture of both hematologic and solid tumors. We examine the molecular crosstalk between JAK/STAT activation and key immune subsets within the TME and discuss the rationale for repurposing JAK inhibitors-established agents for autoimmune disorders-as adjuvants to immunotherapy. Emerging preclinical and clinical evidence suggests that combining selective JAK inhibition with PD-1 blockade can disrupt inflammatory feedback loops, reprogram the TME, and overcome resistance to immune checkpoint inhibitors. This synergistic strategy represents a promising therapeutic frontier for improving outcomes in refractory malignancies.
Numerical simulations identify seismic indicators of extensional detachment faults in rifted margins, suggesting a new approach to understanding their formation.
Review examines thermal degradation pathways of lignocellulosic components, suggesting improved bioenergy processes.
Shows that STMN2 regulates neuronal invasion in small cell lung cancer, indicating a new target for therapy.
AptEx-ID identifies membrane proteins in extracellular vesicles from hepatocellular carcinoma, suggesting new insights into immunotherapy response.
Demonstrates how decidual stromal cells influence immune tolerance and NK cell differentiation in early pregnancy, suggesting therapeutic targets for preventing spontaneous abortion.
This method detects methylated genes in urine samples, suggesting improved diagnosis and prognosis for bladder cancer.
Integrates habitat suitability and abundance to assess invasion risk in Xanthium spinosum, indicating critical management needs.
Longitudinal observational study shows enhanced CSF coupling in post-stroke aphasia after language therapy, suggesting improved brain interaction.
Analysis uncovers genetic profiles and treatment effectiveness of EGFR-TKIs in NSCLC patients, suggesting tailored approaches.
Pilot study shows improved clinical competence in pediatric CPR training, highlighting innovative teaching methods.
Analysis shows sugar metabolism regulation in common bean leaves under alkaline salt stress, suggesting pathways for salt-tolerance.