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← Gerard C. Grosveld

Papers by Gerard C. Grosveld

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  1. Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase DomainInternational Journal of Molecular Sciences · 2024
  2. Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain2024
  3. mTORC3 activity is regulated by GSK3β through the activation of PKCδ that phosphorylates and activates STAT12024
  4. Mitochondrial proteostasis mediated by CRL5 Ozz and Alix maintains skeletal muscle function2023
  5. Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in miceCommunications Biology · 2022
  6. Targeting KDM4 for treating PAX3-FOXO1–driven alveolar rhabdomyosarcomaScience Translational Medicine · 2022
  7. Lysosomes and Cancer Progression: A Malignant LiaisonFrontiers in Cell and Developmental Biology · 2021
  8. MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostatNature Communications · 2019
  9. ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancerScience Advances · 2018
  10. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesisJCI Insight · 2017
  11. DEK protein level is a biomarker of CD138positive normal and malignant plasma cellsPLoS ONE · 2017
  12. Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-CellsDiabetes · 2015
  13. Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 NucleasePLoS Genetics · 2015
  14. Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor CellsCell Reports · 2013
  15. PAX3-FOXO1 Induces Up-Regulation of Noxa Sensitizing Alveolar Rhabdomyosarcoma Cells to ApoptosisNeoplasia · 2013
  16. Mapping of MN1 Sequences Necessary for Myeloid TransformationPLoS ONE · 2013
  17. Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathwayDisease Models & Mechanisms · 2013
  18. The Leukemia-Associated Fusion Protein MN1-TEL Blocks TEL-Specific Recognition SequencesPLoS ONE · 2012
  19. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia.2012
  20. Alveolar rhabdomyosarcoma – The molecular drivers of PAX3/7-FOXO1-induced tumorigenesisSkeletal Muscle · 2012
  21. PAX3-FOXO1 Induces Cannabinoid Receptor 1 to Enhance Cell Invasion and MetastasisCancer Research · 2011
  22. PAX3‐FOXO1 and FGFR4 in alveolar rhabdomyosarcomaMolecular Carcinogenesis · 2011
  23. IRIZIO : a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS)Carcinogenesis · 2010
  24. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivoThe Journal of Experimental Medicine · 2009
  25. Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiationBlood · 2009
  26. Overexpression of the Cellular DEK Protein Promotes Epithelial Transformation In vitro and In vivoCancer Research · 2009
  27. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expressionCarcinogenesis · 2008
  28. Detection of the Philadelphia chromosome in interphase nucleiCytogenetics and Cell Genetics · 2008
  29. Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in MiceCancer Research · 2007
  30. Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine PharmacodynamicsCancer Research · 2007
  31. The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequenceJournal of Molecular Endocrinology · 2006
  32. Negative Regulation of the RelA/p65 Transactivation Function by the Product of the DEK Proto-oncogeneJournal of Biological Chemistry · 2006
  33. FoxO1a-Cyclic GMP-Dependent Kinase I Interactions Orchestrate Myoblast FusionMolecular and Cellular Biology · 2005
  34. Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9Blood · 2005
  35. MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in miceBlood · 2005
  36. The Novel ETS Factor TEL2 Cooperates with Myc in B LymphomagenesisMolecular and Cellular Biology · 2005
  37. The TALE Homeodomain Protein Pbx2 Is Not Essential for Development and Long-Term SurvivalMolecular and Cellular Biology · 2004
  38. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein DekJournal of Cell Science · 2002
  39. The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming ActivityMolecular and Cellular Biology · 2000
  40. The Acute Myeloid Leukemia-Associated Protein, Dek, Forms a Splicing-Dependent Interaction with Exon-Product ComplexesThe Journal of Cell Biology · 2000
  41. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6Blood · 2000
  42. INK4d-Deficient Mice Are Fertile Despite Testicular AtrophyMolecular and Cellular Biology · 2000
  43. Tel, a Frequent Target of Leukemic Translocations, Induces Cellular Aggregation and Influences Expression of Extracellular Matrix ComponentsNeoplasia · 1999
  44. Overexpression of the Nucleoporin CAN/NUP214 Induces Growth Arrest, Nucleocytoplasmic Transport Defects, and ApoptosisMolecular and Cellular Biology · 1998
  45. Identification of new partner chromosomes involved in fusions with theETV6 (TEL) gene in hematologic malignanciesGenes Chromosomes and Cancer · 1998
  46. 12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic LeukemiaBlood · 1997
  47. 12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic LeukemiaBlood · 1997
  48. Development of high-titer retroviral producer cell lines by using Cre-mediated recombinationJournal of Virology · 1997
  49. DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancerProceedings of the National Academy of Sciences · 1997
  50. TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.Journal of Clinical Oncology · 1997