60 pubs · 1,439 cites · h-index 16
The purpose of our study is to examine the outcome of patients undergoing outpatient total hip arthroplasty with a BMI >35. Case-control matching on age, gender (46% female;54%male), and ASA (mean 2.8) with 51 outpatients BMI≥35 kg/m 2 (mean of 40 (35–55)), mean age of 61 (38–78) matched to 51 outpatients BMI<35 kg/m 2 (mean of 27 (17–34)) mean age 61 (33–78). Subsequently 47 inpatients BMI≥35 kg/m 2 (mean of 40 (35–55)) mean age 62 (34–77) were matched outpatients BMI≥35 kg/m 2 . For each cohort, adverse events, readmission in 90 days, reoperations were recorded. Rate of adverse events was significantly higher in BMI ≥35: 15.69% verus 1.96% (p=0.039) with 5 reoperations in the BMI≥35 cohort vs 0 in the BMI<35 kg/m 2 (p= 0.063). Readmissions did not differ between groups (p=0.125). No significant difference for all studied outcomes between the outpatient and inpatients cohorts with BMI≥35 kg/m 2 . The most complications requiring surgery/medical intervention (3B) were in the inpatient cohort of patients >35. The prevalence of Diabetes and Obstructive Sleep apnea was 21.6% and 29.4% for BMI>35 compared to 9.8% and 11.8%, for BMI <35, respectively. Severely obese patients have an overall higher rate of adverse events and reoperations however it should not be used a sole variable for deciding if the patient should be admitted or not.
The first indirect drive Inertial Confinement Fusion (ICF) experiments on the Laser Megajoule facility were carried out with approximately 150 kJ of laser energy distributed on 48 beams (12 quads) arranged in two cones. The target consisted of a gold vacuum rugby-shaped hohlraum and a plastic capsule located at its center, filled with deuterium gas fuel. The arrangement of the 12 quads is such that the laser irradiation on the wall generated a three-dimensional (3D) x-ray flux around the capsule creating 3D deformations on the imploding plastic shell. This constraint forced the design of a robust target (relatively thin ablator, around 40 μm) driven by a short laser pulse (3 ns) that delivered about 1011 neutrons. Full-integrated 3D radiation hydrodynamics simulations allowed both the target definition and the data interpretation (mainly radiation temperature, x-ray images, and neutron yield). 3D calculations and experiments compare well.
Obesity epidemic continues to spread and obesity rates are increasing in the world. In addition to public health effort to reduce obesity, there is a need to better understand the underlying biology to enable more effective treatment and the discovery of new pharmacological agents. Abhydrolase domain-containing protein 11 (ABHD11) is a serine hydrolase enzyme, localized in mitochondria, that can synthesize the endocannabinoid 2-arachidonoyl glycerol (2AG) in vitro. In vivo preclinical studies demonstrated that knock-out ABHD11 mice have a similar 2AG level as WT mice and exhibit a lean metabolic phenotype. Such mice resist to weight gain in Diet Induced Obesity studies (DIO) and display normal biochemical plasma parameters. Metabolic and transcriptomic analyses on serum and tissues of ABHD11 KO mice from DIO studies show a modulation in bile salts associated with reduced fat intestinal absorption. These data suggest that modulating ABHD11 signaling pathway could be of therapeutic value for the treatment of metabolic disorders.
Two-dimensionnal (2D) radiation hydrodynamics codes are the workhorses with which current inertial confinement fusion (ICF) and high energy density (HED) experiments are most often prepared and analyzed. Yet significant scientific and programmatic benefits can be gained from a 3D capability. The TROLL code at CEA DAM is meant to address this need. This article illustrates the phases of integrated verification and physical validation through which this project is currently progressing.
Highly resolved radiation-hydrodynamics FCI2 simulations have been performed to model laser experiments on the National Ignition Facility. In these experiments, cylindrical gas-filled hohlraums with gold walls are driven by a 20 ns laser pulse. For the first time, simulations show the appearance of Kelvin-Helmholtz (KH) vortices at the interface between the expanding wall material and the gas fill. In this paper, we determine the mechanisms which generate this instability: the increase of the gas pressure around the expanding gold plasma leads to the aggregation of an over-dense gold layer simultaneously with shear flows. At the surface of this layer, all the conditions are met for a KH instability to grow. Later on, as the interface decelerates, the Rayleigh-Taylor instability also comes into play. A potential scenario for the generation of a mixing zone at the gold-gas interface due to the KH instability is presented. Our estimates of the Reynolds number and the plasma diffusion width at the interface support the possibility of such a mix. The key role of the first nanosecond of the laser pulse in the instability occurrence is also underlined.
Gas-filled rugby-shaped hohlraums have demonstrated high performances compared to a classical similar diameter cylinder hohlraum with a nearly 40% increase of x-ray drive, 10% higher measured peak drive temperature, and an increase in neutron production. Experimental comparisons have been done between rugby, cylinder, and elliptical hohlraums. The impact of these geometry differences on the laser plasma instabilities is examined. Using comparisons with hydrodynamic simulations carried out with the code FCI2 and postprocessed by Piranah, we have been able to reproduce the stimulated Raman and Brillouin scattering spectrum of the different beams. Using a methodology based on a statistical analysis for the gain calculations, we show that the behavior of the laser plasma instabilities in rugby hohlraums can be reproduced. The efficiency of laser smoothing techniques to mitigate these instabilities are discussed, and we show that while rugby hohlraums exhibit more laser plasma instabilities than cylinder hohlraum, the latter can be mitigated in the case of an elliptical hohlraum.
A direct experimental comparison of rugby-shaped and cylindrical shaped gas-filled hohlraums on the Omega laser facility demonstrates that higher coupling and minimal backscatter can be achieved in the rugby geometry, leading to significantly enhanced implosion performance. A nearly 50% increase of x-ray drive is associated with earlier bangtime and increase of neutron production. The observed drive enhancement from rugby geometry in this study is almost twice stronger than in previously published results.
Targets designed to produce ignition on the Laser Megajoule (LMJ) are being simulated in order to set specifications for target fabrication. The LMJ experimental plans include the attempt of ignition and burn of an ICF capsule with 160 laser beams, delivering up to 1.4 MJ and 380 TW. New targets needing reduced laser energy with only a small decrease in robustness have then been designed for this purpose. Working specifically on the coupling efficiency parameter, i.e. the ratio of the energy absorbed by the capsule to the laser energy, has led to the design of a rugby-ball shaped cocktail hohlraum; with these improvements, a target based on the 240-beam A1040 capsule can be included in the 160-beam laser energy-power space. Robustness evaluations of these different targets shed light on critical points for ignition, which can trade off by tightening some specifications or by preliminary experimental and numerical tuning experiments.
The first ignition experiments on the Laser Mégajoule facility will use an indirect drive scheme. Our A1040 point design target is a graded doped plastic capsule filled by permeation within a gold cylinder. The deuterium-tritium ice layer may be formed either by classical slow cooling at 1.5 K below triple point, or by rapid cooling at 2.3 K below triple point. To complete the specifications, we first studied the robustness to all technological defects with the current CEA capabilities for these two options of ice formation. The technological imperfections taken into account are regrouped into 1D errors, which keep the implosion spherical, and 3D errors, which induce a deformation of the shell. The 3D robustness is expressed in terms of deformation at peak velocity and compared to the deformation threshold obtained with 2D simulations. The 1D robustness is given by the probability of exceeding 50% of nominal yield. We have taken into account 22 1D parameters and the fusion energy is approximated by a neural network based on 2000 simulations. Although the studies are not finished yet, the first results show that the A1040 design with rapid cooling has sufficient margins with respect to technological defects.
The adoption of a non-uniform dopant profile has substantially increased the tolerance to high mode deformations of our baseline indirect-drive design. In addition, a low deuterium–tritium (DT) gas density, obtained by 'dynamic quenching' at 2.3 K below triple point, could partly compensate for the decrease in robustness due to DT ageing. Finally, the net margin regarding all laser and target technological defects is about 2. As soon as a sufficient amount of laser beams and diagnostics is available, we will shoot pre-ignition experiments to tune the point design. We are studying new targets which need less energy for these campaigns.We have estimated different direct-drive schemes using indirect-drive beams. The optimal LMJ polar direct-drive configuration is a 2-cone one and leads to marginally igniting targets. A new 2-cone direct-drive scheme, associated with focal spot zooming, allows us to reach ignition with enough margin.
First we report two studies aimed at preparing laser integration line (LIL) experiments (LIL is the prototype of LMJ): deflection of a beam with and without 'longitudinal' smoothing (associated with focusing by gratings) and the radiation temperature, Tr, in a hohlraum with long pulses (10–20 ns). Experimentally, we did not see any Langmuir decay instability able to saturate the stimulated Raman scattering in a gas bag irradiated with the Omega laser. Next, in our hydro-code FCI2, we implemented an improved version of the non-LTE atomic physics model: the change in Tr in the hohlraum is negligible, but now the simulations are in agreement with experiments on x-ray conversion and on Rayleigh–Taylor instabilities (RTIs) in a spherical geometry. The RTIs in polyimide foil at 70 µm were understood, but not those at 30 µm. Finally, for the target design, we confirm the hydro-stability of the four targets of the operational domain of LMJ: the doped CH ablator of the nominal target can withstand a roughness in the range 50–100 nm. The robustness studies use 19 uncertainties coming from the laser power, the beam pointing and the target fabrication. Finally, the burning of DT has been studied in detail, identifying three regimes.
By means of highly resolved one-dimensional hydrodynamics simulations, we provide an understanding of the burn process in inertial-confinement-fusion baseline targets. The cornerstone of the phenomenology of propagating burn in such laser-driven capsules is shown to be the transition from a slow unsteady reaction-diffusion regime of thermonuclear combustion (some sort of deflagration) to a fast detonative one. Remarkably, detonation initiation follows the slowing down of a shockless supersonic reaction wave driven by energy redeposition from the fusion products themselves. Such a route to detonation is specific to fusion plasmas.
We report an experimental, numerical, and analytical study of the near resonant propagation of a laser pulse through an atomic vapor. In the nonlinear regime probed, the light pulse develops frequency sidebands whose positions are, in first approximation, solely dependent on the maximum Rabi frequency of the system, in a fashion very similar to that observed in optical fibers. This modulational instability dictates the temporal reshaping of the laser field and finally results in pulse splitting.
A model aimed at describing the electronic structure of hot dense plasmas is presented. This model is first used to study the effect of the nearest neighbor interaction on the photoabsorption K-edge position in a dense fluorine plasma. Changes to the ionization potential lowering from the well-known ion sphere model [H. Nguyen et al., Phys. Rev. A 33, 1279 (1986)] are obtained by the present approach for plasma density above solid. We believe that this effect could be of importance in the calculation of the opacity of dense materials. The present model also provides an alternative to the treatment of line broadening in very dense plasmas where the average interionic spacing can be of the order of the spatial extent of the excited-state orbitals. To illustrate this point, we present F Lyman-{β} line shapes for various density conditions.
The relative yields of different charge states of surface-scattered and -recoiled ions, from amorphous aluminum, with 10-keV N⁺, Ne⁺, and O⁺ incident ions, have been measured as a function of the time which the outgoing particles spend interacting with the surface. During this time the atomic states with 2p shell vacancies from the close binary encounter are converted by the various Auger and resonance processes into ions outside the surface. The characteristic velocities are found to be comparable to or less than those for a silicon surface. A model is proposed in which Auger neutralization inside the surface mainly determines the proportion of atoms with 2p shell vacancies become ionic states outside the surface. {} 1996 The American Physical Society.
A cylindrical electrode electrostatic analyzer has been designed for surface structure measurements which has sufficient sensitivity that shadowing/blocking data can be obtained without significantly damaging the surface structure. A modification to the standard π/√2 design compensates for that part of the spread in the ion energies due to elastic scattering kinematics. The analyzer is small enough to fit inside a standard 25 cm diameter UHV chamber on a turntable, allowing angular distribution measurements over a wide range of scattering angles. An example of a shadowing/blocking angular scan of a clean Si(100) surface is shown.
We describe an instrument that images the Alcator A tokamak plasma in the soft x-ray energy range with high temporal resolution. Radiation from a cross section of the plasma column is detected by an array of seventeen surface barrier detectors which provides 1 cm poloidal spatial resolution over a 16 cm field of view. The instrument’s nominal sensitivity lies in the spectral range from 0.27 to 25 keV; this range includes much of the radiation emitted by the Alcator A plasma, whose core temperature is typically in the 0.6 to 1.1 keV range. The frequency response of the detector-electronics system extends from dc to 170 kHz. We discuss: (1) some design considerations and instrument calibrations, including the instrument’s measured response to 0.28, 1.5, 8.0, and 17.5 keV x-rays and its theoretical response to a bremsstrahlung spectrum; (2) the detector-electronics noise levels under various conditions; (3) the instrument’s response to an electrically modulated x-ray source; (4) the detector x-ray response as a function of bias voltage and temperature; (5) the detector linearity of response to 1.5 keV x-rays; and (6) the stability of the detector x-ray response despite numerous and prolonged vacuum breaks. Sample data, obtained from Alcator A discharges, are presented.