Atopic dermatitis (AD) is a chronic, relapsing inflammatory dermatosis that profoundly impacts the physical, emotional, and psychosocial well-being of patients. Clinically characterized by xerosis, eczematous lesions, and intense pruritus, AD often follows a lifelong fluctuating course. With rising global prevalence, particularly in industrialized countries, the burden of AD has prompted significant research into its pathophysiology and therapeutic options. Recent discoveries highlight the central role of immune dysregulation, skin barrier dysfunction, and genetic predisposition—leading to innovative treatment approaches. This review explores the dermatological manifestations of AD, recent advances in targeted therapies including biologics and Janus kinase (JAK) inhibitors, and emerging precision medicine strategies poised to transform long-term management.
Verónica et al. (Mon,) studied this question.