Figure S3 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• RGN6024 effectively targets glioblastoma by acting as a tubulin destabilizer.
• The compound is brain-penetrant, allowing it to reach tumor sites more effectively.
• Non-tumorigenic microglial cells showed improved viability with RGN6024 treatment.
• This research highlights new potential therapies for glioblastoma using small-molecule drugs.