In recent years, cosmeceuticals have emerged as a dynamic hybrid between cosmetics and pharmaceuticals, offering not only aesthetic enhancement but also therapeutic benefits for various skin conditions. This review highlights the cutting-edge advancements in cosmeceuticals used in skincare, with a particular focus on novel bioactive ingredients, innovative delivery systems, and personalized approaches. The evolution of cosmeceutical science has been significantly influenced by breakthroughs in nanotechnology, biotechnology, and molecular dermatology, leading to the development of highly stable and effective formulations that penetrate deeper skin layers with greater precision. Emerging compounds such as peptides, growth factors, botanical antioxidants, and marine-derived actives have shown promising results in anti-aging, pigmentation correction, acne management, and barrier repair. Moreover, nanocarriers like liposomes, ethosomes, solid lipid nanoparticles, and dendrimers have revolutionized delivery systems, ensuring targeted and controlled release of active agents. This paper also explores the integration of omics technologies and artificial intelligence in designing personalized skincare regimens based on genetic, environmental, and lifestyle factors. Consumer demand for sustainable, cruelty-free, and "clean label" formulations has further fueled innovation in natural and plant-based cosmeceuticals. The future of skincare lies in multifunctional cosmeceuticals that blend efficacy with safety, supported by rigorous scientific validation and regulatory compliance. This review provides a comprehensive overview of recent advancements and sets the foundation for future research, highlighting the immense potential of cosmeceuticals as a cornerstone in modern dermatological care.
Shukla et al. (Sun,) studied this question.