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August 20, 2025Open Access

The importance of dopamine levels and single-nucleotide polymorphism within COMT , DRD1 and DRD2 genes in obstructive sleep apnoea

JSJoanna SmardzWroclaw Medical University HMHelena MartynowiczWroclaw Medical University MDMarta Dratwa-KuźminLudwik Hirszfeld Institute of Immunology and Experimental Therapy

Key Points

Dopamine levels significantly influence the pathophysiology of obstructive sleep apnoea, highlighting its neurobiological aspects.
Key evidence includes the relationship between specific genetic variations in COMT, DRD1, and DRD2 contributing to OSA.
Using genetic analysis, the study identifies the role of single-nucleotide polymorphisms in these dopamine-related genes in OSA.
Identifying genetic modulations may enable better understanding and future interventions for obstructive sleep apnoea.

Abstract

Background Obstructive sleep apnoea (OSA) is a prevalent sleep disorder that contributes to serious cardiovascular comorbidities. While the mechanical aspects of OSA are well-studied, its neurobiological underpinnings remain underexplored. In this study, we investigated the role of dopamine and its genetic modulators in OSA pathophysiology.

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