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August 20, 2025

Trends in Antepartum, Delivery, and Postpartum Venous Thromboembolism

Key Points

Venous thromboembolism risk has increased in recent years among pregnant women, and significant clinical factors are associated.
VTE diagnoses showed a notable rise, particularly deep vein thrombosis and pulmonary embolism, in the study period.
Using data from over 1.9 million pregnancies, the analysis focused on medically confirmed VTE risk from 2008 to 2019.
The findings underscore the necessity for improved screening and management strategies during pregnancy and the postpartum period.

Abstract

( Obstet Gynecol . 2025;145(3):e98–e106. DOI: 10.1097/AOG.0000000000005818) This study examined national trends in obstetric venous thromboembolism (VTE)—including deep vein thrombosis (DVT) and pulmonary embolism (PE)—during pregnancy, delivery, and the postpartum period. Using data from the 2008 to 2019 Merative MarketScan Commercial Claims and Encounters and Medicaid Multi-State databases, the authors analyzed over 1.9 million pregnancies to determine whether VTE risk increased over time and which clinical factors were associated. The researchers identified women aged 15 to 54 who had delivery hospitalizations and were enrolled in health plans for at least 1 year before pregnancy through 60 days postpartum. VTE diagnoses were confirmed using medical codes alongside pharmacy records indicating anticoagulant use, improving identification accuracy compared with prior studies that relied solely on administrative codes.

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