June 30, 2024

Study of Impact Monosodium Glutamate on Histology, and Oxidative Stress in Adult Female Rats and The Protective Role of Vitamine B12

Key Points

Monosodium glutamate exposure leads to significant histological changes in brain tissues, along with signs of oxidative stress.
After treatment with vitamin B12, improvements in malondialdehyde and glutathione levels were observed, indicating protective effects.
The study involved five groups of female rats, with doses of MSG and vitamin B12 administered over 30 and 60 days.
These findings highlight the potential neuroprotective role of vitamin B12 against monosodium glutamate-induced damage.

Abstract

Glutamate is one of the most exciting neurotransmitters in the brain. The current study investigates the effect of Monosodium glutamate (MSG) on Serum level of that include malondialdehyde MDA and Monosodium glutamate GSH levels. Histological changes in the brain, and protective effect of vitamin B12. Rats were divided into five equal groups n=10, each group was further divided into two groups (A and B, n=5) and treated for 30 and 60 days, respectively. The 1st group received distilled water orally by gavage, while 2nd and 3rd group received MSG in a dose of 25 and 45 mg/kg body weight orally by gavage. The 4th and 5th groups received MSG and vitamin B12 in a dose of 25 or 45 mg MSG/kg in addition to 0.3m vitamin B12/kg. Monosodium glutamate causes a significant histopathological change in brain tissue. However, MDE, and GSH were not significantly altered. These changes were reversed by treatment with vitamin B12. Degenerative, degeneration and necrosis of the supporting cells of astrocytes. There was an improvement in the levels of MDA and GSH as well as brain tissue.

KI fragen

Bookmark

View Full Paper