Facile N-directed Ru-catalyzed C(3)-H acylation of heterocyclopentadienes with acyl chlorides

Key Points

• The research shows selective C3-H acylation of heterocyclopentadienes, which is a significant advancement in C-H functionalization.
• Selectivity is achieved against competing C4 and C5-H sites, indicating the effectiveness of this N-directed method.
• The study utilized a Ru-catalyzed approach to perform the C(3)-H acylation using acyl chlorides as acylating agents.
• These findings highlight the potential for further exploration in C-H activation techniques and functionalization strategies.

Abstract