What type of study is this?

This is a Cross-Sectional study.

September 10, 2025

Echocardiographic Changes in Patients of Chronic Obstructive Pulmonary Disease and Its Correlation With Severity of Disease and High Sensitivity Serum CRP Values

Key Points

Echocardiographic abnormalities are prevalent in COPD patients, with pulmonary hypertension found in 50% of cases.
A significant correlation was noted between COPD severity and echocardiographic changes, including right ventricular dilation.
Higher hs-CRP levels were found in patients with cardiac complications, indicating a link between systemic inflammation and COPD severity.
Integrating echocardiographic evaluations and inflammatory markers may improve early diagnosis and management of COPD patients.

Abstract

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a major global health issue, characterized by chronic inflammation and airflow limitation. Systemic inflammation in COPD patients is commonly assessed through biomarkers like high-sensitivity C-reactive protein (hs-CRP). Objectives: To evaluate the 2D Echo changes and correlation with severity of disease (FEV1) & hs-CRP in COPD. Methodology: A crosssectional study was conducted involving 106 COPD patients.After obtaining written informed consent, demographic details, smoking habits, environmental exposure to biomass fuels, and COPD severity were recorded. hs-CRPlevels were measured as a marker of systemic inflammation. Echocardiographic evaluations were performed to assess cardiac complications. Descriptive statistics were used to analyze demographic and clinical data. Results: Echocardiographic abnormalities were common, with PH present in 50% of patients, increasing with disease severity (p < 0.001). Right ventricular dilation (RVd) was seen in 41.5% of cases, while left ventricular systolic dysfunction (LVSD) and diastolic dysfunction (LVDD) were noted in 8.49% and 13.21% of patients, respectively. A significant association was found between COPD severity and PH, LVSD, LVDD, and RVd (p < 0.001). hs-CRP levels were significantly higher in patients with PH (76.61 ±74.18 mg/L), LVSD (97.68 ±68.35 mg/L), LVDD (94.80 ±57.49 mg/L), and RVd (79.02 ±73.69 mg/L), indicating a strong link between systemic inflammation and cardiac complications in COPD (p < 0.001). Conclusions: Echocardiographic abnormalities are significantly associated with COPD severity and systemic inflammation. hs-CRP serves as a valuable biomarker for identifying high-risk patients. Integrating echocardiographic evaluation and inflammatory markers in COPD management can aid in early diagnosis and targeted interventions for better patient outcomes.

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