Detailed Insights Into Water‐Assisted Approaches Toward the Synthesis of Pyrazole Derivatives

Abstract Green synthesis is important in organic synthesis nowadays. Increasing awareness of the need for eco‐friendly technology has led to the use of green techniques in precision chemical and pharmaceutical development. Alternative reaction media that reduce the problems of volatile organic solvents are also gaining popularity. Innovation in reaction media for eco‐friendly, sustainable organic synthesis and the development of important organic heterocycles. Pyrazole and its derivatives are preferred organic heterocycle structures for lead compound identification in the discovery of new synthetic pharmaceutical molecules and other key possibilities. Numerous commercial drugs, such as sildenafil, rimonabant, and celecoxib, in biological and preclinical trials demonstrate the therapeutic breadth of this pharmacological scaffold category. As a green solvent, water is essential for pyrazole derivative synthesis and a convenient reaction medium for organic chemists. This review discusses water's eco‐friendly role in pyrazole derivative synthesis.