Metal-Free C(sp3)–Si Activation Enables Regiocontrolled 4+2 Cycloaddition to Benzosilacycloethers

Key Points

• The method enables regioselective [4+2] cycloaddition of benzosilacyclobutanes with activated ketones.
• DMSO acts as a mild Lewis base to facilitate the cycloaddition process effectively.
• This sustainable, transition-metal-free approach offers a novel strategy for chemical synthesis.
• The findings suggest that metal-free conditions can lead to valuable synthetic routes in organic chemistry.