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September 10, 2025Open Access

High diagnostic accuracy of pooled samples analysed with a commercial PCR for detecting MRSA carriage

Key Points

High diagnostic accuracy was achieved with pooled samples for detecting MRSA carriage.
The Xpert MRSA NxG kit demonstrated 95% sensitivity and 99% specificity in a large patient cohort.
This approach highlights the effectiveness of pooled PCR testing in resource-limited settings.
Further research could validate these findings across different populations to confirm broader applicability.

Abstract

We evaluated the diagnostic accuracy of two Cepheid Xpert MRSA assay generations using pooled samples from 4,519 patients to detect MRSA carriage in a low-prevalence population. High accuracy, including 95 % sensitivity and 99 % specificity was shown for the Xpert MRSA NxG kit. This supports pooled PCR as a resource-efficient method.

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