Abstract Aims Coronavirus disease 2019 (COVID-19) may trigger myocardial infarction (MI). However, the outcomes of MI following recent COVID-19 remain largely unexplored. Consequently, we examined the association between recent COVID-19 and mortality after MI and the prognostic importance of COVID-19 vaccination. Methods With data from linked Danish registries, we conducted a nationwide, population-based cohort study including adults admitted with a first-time MI to a Danish hospital from May 26, 2020, to March 9, 2022. The exposure was recent COVID-19 (positive polymerase chain reaction test in the period from 90 days before to the day after MI). Primary outcomes were all-cause mortality within 30 or 180 days after MI. We calculated absolute risk estimates and computed hazard ratios (HRs) with 95% confidence intervals (CIs) with a Cox proportional-hazards regression controlled for age, sex, comorbidity burden, and use of selected drugs using stabilized inverse probability weighting. We stratified by prior COVID-19 vaccination. Results Of 12,054 included MI patients, 337 had recent COVID-19. Comparison of MI patients with versus without recent COVID-19 yielded an adjusted HR of 1.64 (95% CI: 1.16–2.31) for 30-day mortality and 1.28 (95% CI: 0.92–1.78) for 180-day mortality after MI. The adjusted HR was higher among unvaccinated MI patients (2.88, 95% CI: 1.78–4.64 for 30-day mortality; 2.09, 95% CI: 1.30–3.36 for 180-day mortality) than vaccinated patients (1.11, 95% CI: 0.65–1.90 and 0.97, 95% CI: 0.60–1.56, respectively). Conclusion Recent COVID-19 was associated with increased short-term mortality after MI in patients without prior COVID-19 vaccination.
Brodersen et al. (Tue,) studied this question.