September 16, 2025

Initial Experience of Cardiac Multi-parametric Mapping at 5.0T with Single-shot Cartesian Acquisition and Dictionary Matching

Key Points

T1 and T2 values can be accurately estimated using multi-parametric mapping at 5.0T, enhancing myocardial assessments.
Validation trials showed promising performance for simultaneous myocardial mapping techniques in clinical settings.
Single-shot Cartesian acquisition and dictionary-based techniques improved robustness against field inhomogeneity effects.
Focus on using B1+ correction methods indicates the potential for improved quantification accuracy in myocardial studies.

Abstract

Motivation: While 5.0T ultra-high field MRI offers superior resolution and signal-to-noise ratio, it introduces pronounced field inhomogeneity effects, which hinders myocardial quantification approaches. Goal(s): To validate the feasibility of simultaneous myocardial multi-parametric mapping (MultiMap) on a 5.0T MRI scanner. Approach: Cardiac MultiMap was implemented at 5.0T using single-shot Cartesian acquisition and dictionary-based quantification with pixel-wise B1+ correction, replacing bSSFP with FLASH readout to improve robustness to B0 field inhomogeneity. Quantification accuracy was evaluated through phantom and in-vivo experiments. Results: T1 and T2 can be accurately estimated using MultiMap at 5.0T. Impact: The validation of simultaneous myocardial multi-parametric mapping at 5.0T demonstrated promising performance, with potential for more accurate myocardial assessments in clinical settings.

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