What type of study is this?

This is a Human Clinical Trial study.

September 17, 2025

Phase-Based R2 Mapping for Single Breath-Hold Whole-Liver Iron Quantification : Clinical Validation

Key Points

PB-R2 mapping provides rapid and accurate liver iron quantification, enhancing patient comfort during MRI exams.
PB-R2 mapping demonstrated good agreement with traditional methods across a broad range of iron concentrations.
The technique uses RF phase-modulated 3D GRE imaging tested at both 1.5T and 3.0T MRI for reliable measurements.
The study highlights the potential of PB-R2 mapping to improve the assessment of liver iron overload while addressing fat bias.

Abstract

Motivation: Liver iron overload can cause serious complications; accurate assessment is essential. Current R2 mapping techniques are limited by long scan times and fat-induced bias. Goal(s): To validate a rapid phase-based (PB) R2 mapping method for whole-liver iron quantification by comparing it with conventional methods, and to understand fat bias through simulations. Approach: PB-R2 mapping using RF phase-modulated 3D GRE imaging was tested in patients with iron overload at 1.5T and 3.0T MRI. Results: PB-R2 mapping showed good agreement with reference methods over a wide range of iron concentrations and excellent repeatability. Impact: PB-R2 mapping enables rapid, accurate whole-liver iron quantification within a single breath-hold, enhancing clinical efficiency and patient comfort. It may improve iron overload assessment and inspire further research to address fat bias in R2 mapping.

Bookmark

Cite This Study

Tamada et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4596631b076d99fa5c1df https://doi.org/https://doi.org/10.58530/2025/2664

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Bookmark