What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Simultaneous Myelin and Myelin Water Mapping Using Dual-Echo STAIR-Cones Sequence

Key Points

The dual-echo STAIR-Cones sequence effectively measures myelin proton fraction and myelin water fraction.
Quantified values of MPF and MWF are comparable to those from previous studies using distinct sequences.
Three volunteers were scanned, showcasing the feasibility of a single sequence for myelin imaging.
Using this combined method could advance understanding of neuroinflammatory and neurodegenerative diseases.

Abstract

Motivation: Myelin proton fraction (MPF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of neurodegeneration but require two distinct sequences. Goal(s): We aim to measure both the MPF and MWF with a single dual-echo (DE)-STAIR-Cones sequence. Approach: Three volunteers were scanned with the DE-STAIR-Cones sequence for myelin and MW mapping, on a 3T clinical scanner. Results: The single sequence successfully quantified the MPF, with and without decay correction, and the MWF with values comparable to those of previous studies. Impact: The DE-STAIR-Cones, as a singular sequence, can measure the myelin imaging biomarkers of MPF and MWF, which may help in understanding the mechanism of these myelin imaging biomarkers for the assessment of neuroinflammatory/neurodegenerative diseases.

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