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September 17, 2025

Lumbar disc degeneration is significant correlated with lumbar spine volumetric BMD in male patients with NSLBP, except for the L5/S1 disc

Key Points

Lumbar disc degeneration negatively correlates with volumetric BMD in male NSLBP patients, impacting treatment approaches.
The independent influencing factor on volumetric BMD in this population is the extent of degeneration at the L1/2-L4/5 disc.
Using MRI to assess lumbar disc degeneration can help predict osteoporosis in male patients with non-specific low back pain.
Potential complications like osteoporotic fractures may be reduced with a deeper understanding of this relationship.

Abstract

Motivation: Lumbar disc degeneration (LDD) and osteoporosis (OP) are both possible contributors to non-specific low back pain (NSLBP). However, the relationship between LDD and volumetric bone mineral density (vBMD) used to assess OP remains unclear in men. Goal(s): To investigate the relationship between LDD and vBMD in male NSLBP patients. Approach: We assessed the relationship between the extent of LDD, obtained from MRI, and vBMD of vertebral bodies, measured using quantitative CT, in male NSLBP patients. Results: Our results showed that LDD was negatively correlated with vBMD in male NSLBP patients, with the L1/2-L4/5 disc being an independent influencing factor of vBMD. Impact: L1/2-L4/5 disc being an independent influencing factor of vBMD in male NSLBP patients. Further investigation can explore if the degree of L1/2-L4/5 intervertebral disc degeneration through MRI can predict OP, thereby reducing the occurrence of complications such as osteoporotic fractures.

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