What type of study is this?

This is a Quantitative Study study.

September 17, 2025

T1 Mapping in the Lungs using a Variable Flip Angle Approach with UTE-MRI

Key Points

T1 estimates matched predicted equations and expected ranges in human lungs, demonstrating reliability.
The approach allows for high-resolution 3D parametric mapping of lung parenchyma during free breathing.
Gadolinium reference standards confirmed the accurate T1 mapping achieved through the variable flip angle method.
This method indicates physiological changes in lung conditions during free breathing, offering clinical relevance.

Abstract

Motivation: We seek a rapid T1 parametric mapping of the lung for quantifying changes in response to ventilation with oxygen during free breathing. Goal(s): Evaluate the Variable Flip Angle (VFA) approach with 3D UTE as a reliable method for T1 mapping in reference standards and human lung. Approach: Reference standards (using Gadolinium) and four healthy participants were imaged using 3D UTE at multiple flip angles. T1 estimates were compared to values from reference standards using inversion recovery protocols. Results: T1 estimates using VFA matched predicted equations in experimental phantoms and expected range in human lung. T1 can be assessed with this free-breathing approach. Impact: The free-breathing VFA-UTE technique provides a simple and time-efficient approach to generate high-resolution 3D parametric mapping of lung parenchyma during free breathing that is sensitive to changes in physiological conditions.

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Cite This Study

Khodaei et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c4ad https://doi.org/https://doi.org/10.58530/2025/2263

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