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September 17, 2025

Influence of RF saturation parameters and CEST quantification metrics on human brain tumor contrast

Key Points

High RF saturation strength with 100% duty cycle significantly enhances tumor contrast.
Among quantification techniques, the EMR technique provides notable improvements in tumor contrast.
Different RF saturation parameters impact the effectiveness of CEST quantification in brain tumors.
CEST metrics must be chosen strategically based on RF saturation settings for optimal assessment.

Abstract

Motivation: RF saturation parameters and CEST quantification metrics can greatly influence brain tumor contrast. Goal(s): To evaluate the effect of RF saturation parameters and different CEST calculation metrics on human brain tumors. Approach: CEST data was acquired from brain tumor patients with different RF saturation strengths and duty cycles (DC). Different quantification techniques including MTR asymmetry, apparent exchange-dependent relaxation (AREX), and extrapolated semisolid MT reference (EMR) were used for CEST quantification and compared. Results: A high RF saturation strength with 100% DC resulted in a good tumor contrast. EMR technique provided an appreciable tumor contrast among the CEST quantification techniques. Impact: This study sheds light on the influence of RF saturation parameters and CEST quantification metrics on brain tumor assessment. The choice of CEST metric must be carefully considered according to RF saturation parameter settings.

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