What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Comparative Assessment of T1w, T2w, and Combined T1w/T2w MRI Images for Perivascular Space Measurement

Key Points

T1w and T2w MRI methods show high correlation with the combined T1w/T2w method for measuring perivascular spaces.
Coefficients of determination (R²) reached 0.98, indicating very strong agreement in PVS volume assessment.
PVS volume measurements were consistently repeatable across T1w, T2w, and combined methods in both pediatric and adult subjects.
Findings suggest that T1w and T2w MRI protocols can be effectively utilized in neurological research and clinical practices.

Abstract

Motivation: Perivascular spaces (PVS) are linked to various neurological disorders, but the desired T1w/T2w MRI is not routinely acquired in clinical imaging. Goal(s): This study evaluates T1- or T2-weighted (T1w and T2w) imaging for PVS measurement compared with the T1w/T2w method. Approach: Using 198 pediatric and 878 subjects from HCP, we compared PVS volumes obtained from T1w or T2w with those from the T1w/T2w method. Results: Coefficients of determination (R²) were 0.89-0.94 and 0.98 for T1w and T2w relative to T1w/T2w, respectively. Higher PVS volumes in males were detected and similar repeatability was achieved with all three methods. Impact: T1w and T2w methods are precise and highly correlated with preferred combined 3D T1w/T2w method for measuring perivascular spaces (PVS) suggesting that clinical MRI protocols with T1w or T2w imaging can have broader applications in neurological research for PVS assessment.

Comparative Assessment of T1w, T2w, and Combined T1w/T2w MRI Images for Perivascular Space Measurement

Key Points

Abstract

Cite This Study

Also Consider

Also Consider