What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Simultaneous 1H/23Na MRF in healthy brain aging: Preliminary data

Key Points

Initial findings indicated no significant differences in sodium and proton MR parameters across ages, hinting at stability in healthy aging.
Data collected from nine healthy volunteers using a 7T scanner with a simultaneous 1H/23Na MRF sequence underlines the exploratory nature of this research.
The study measured sodium and proton densities and their relaxation times in various brain regions including white matter and gray matter for clarity.
Further research is planned to involve a larger cohort and focus on smaller defined regions of the brain to enhance reliability.

Abstract

Motivation: Quantitative sodium brain imaging has shown changes for neurodegenerative diseases and is of interest in healthy brain aging. Goal(s): This study aims to investigate quantitative changes in sodium and proton MR fingerprinting parameters in healthy individuals of different ages. Approach: Data was collected from nine volunteers with a simultaneous 3D 1H/23Na MRF sequence at 7T. The study aimed to measure sodium and proton densities and their relaxation times in white matter, gray matter, and cerebrospinal fluid. Results: Initial findings showed no significant differences in MRF parameters. Further research with a larger cohort and in smaller defined regions of the brain is planned. Impact: Quantitative sodium imaging in the brain can be of high interest for investigating healthy aging. Simultaneous 1H/23Na MRF enables quantification of sodium and proton MR parameters. This study provides insights on age-dependent changes in MR parameters.

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