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September 17, 2025

A comparison of ungated radial SMS and ECG-gated myocardial perfusion MRI

Key Points

The ungated radial SMS sequence estimates myocardial blood flow effectively, matching the accuracy of ECG-gated sequences.
Pixel-wise maps from ungated sequences show reproducibility in measuring myocardial blood flow during studies on canines and humans.
Studying both ungated and gated sequences provides insight into their performance under arrhythmia, demonstrating robustness.
Using ungated sequences may enhance imaging reliability by reducing sensitivity to ECG-related issues seen in conditions like atrial fibrillation.

Abstract

Motivation: Standard ECG-gated saturation recovery sequences can be limited under arrhythmia. However, few studies have compared the performance of ungated and gated saturation recovery sequences using radial simultaneous multi-slice (SMS) sequences. Goal(s): To analyze the accuracy and repeatability of ungated and gated radial SMS sequences. Approach: Pixel-wise myocardial blood flow maps were generated using the Fermi model for five canines and two human subjects. Human studies were performed twice on separate days for repeatability. Results: The ungated radial SMS saturation recovery sequence can be used to quantify resting perfusion myocardial blood flow with similar accuracy and reproducibility to its ECG-gated counterpart. Impact: The ungated radial SMS saturation recovery sequence could allow for increased robustness to ECG-related issues commonly seen in atrial fibrillation.

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Cite This Study

Le et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5c98e https://doi.org/https://doi.org/10.58530/2025/3684

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