Motivation: Utilize the ultra-high field of 10.5 T for human in vivo brain MRSI investigations. Goal(s): 3D mapping of an unprecedented high number of brain metabolites. Approach: Employing a custom-built MR coil together with an optimized shimming tool and a robust FID-MRSI sequence with fast concentric ring readouts. Results: 3D-FID-MRSI via concentric ring trajectory readouts at 10.5 T with nominal 2.75 mm isotropic resolution within 25 minutes. Mapping of up to 13 brain metabolites plus macromolecules such as aspartate, GABA, glucose, glutamine and NAAG. Dedicated parallel transmit and receive coil setup, with up to 80 coils, ensured high SNR and homogenous field distributions. Impact: We have shown for the first time that 1H-FID-MRSI of the human brain at 10.5 T allows for 3D mapping of up to 13 neurochemicals. This technology could offer a unique view into the metabolic intricacies of the human brain.
Hingerl et al. (Tue,) studied this question.