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September 17, 2025

Glymphatic Alterations Mediate Cognitive Dysfunction in Relapsing-Remitting Multiple Sclerosis

Key Points

Cognitive impairment in RRMS patients is linked to glymphatic alterations affecting brain function.
Lower ALPS-index and higher choroid plexus volume were observed in patients with cognitive impairment.
Correlation analysis using DTI-ALPS indexes assessed their link with cognitive performance in multiple sclerosis.
These findings suggest a need for further exploration of glymphatic mechanisms in multiple sclerosis-related cognitive issues.

Abstract

Motivation: Identifying more MRI biomarkers is needed to better understand the pathological processes responsible for relapsing-remitting multiple sclerosis (RRMS)-related cognitive impairment (Co-I). Goal(s): To investigate the association between choroid plexus volume (CPV) and cognition in RRMS and analyze whether it was mediated by the glymphatic function. Approach: 60 MS patients and 44 healthy controls were enrolled. DTI-ALPS indexes were calculated. Correlations between DTI-ALPS and CPV and cognitive performance were analyzed. Results: RRMS patients with Co-I showed lower ALPS-index and higher CP volume. ALPS-index mediated the effect of enlarged CP on cognitive function. Impact: The impact of enlarged CP on cognitive function is mediated by glymphatic alterations, indicating a pathological mechanism for MS-related cognitive impairment.

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Cite This Study

Wang et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b0b31b076d99fa5ceec https://doi.org/https://doi.org/10.58530/2025/3753

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