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September 17, 2025

Single breath-hold EPI-based 3D Late Gadolinium Enhancement Imaging

Key Points

3D LGE images can be reconstructed successfully from a single breath-hold of 19 heartbeats.
The proposed method achieved an undersampling factor of 4, indicating reduced scan time and improved comfort for patients.
This approach involves an inversion recovery-prepared segmented 3D EPI sequence with advanced reconstruction techniques.
Further developments in reconstruction can enhance resolution beyond what is achievable with prolonged free-breathing methods.

Abstract

Motivation: 3D Late Gadolinium Enhanced MRI can suffer from long scan times which can be difficult for some patients to tolerate. Goal(s): Design a 3D single breath-hold LGE-MRI sequence able to acquire whole-heart LGE images. Approach: Implement an inversion recovery-prepared segmented 3D EPI sequence with a blipped-CAIPI undersampling pattern and an iterative SENSE reconstruction. Results: Two patients were scanned with the proposed sequence, demonstrating that 3D whole-heart LGE images can be reconstructed from data acquired during a single, 19 heartbeat breath-hold, with a total undersampling factor of 4. Impact: Using EPI readouts for LGE-MRI allows 3D images to be acquired in one breath-hold, with less undersampling than previously proposed methods. Further developments to the reconstruction could improve the resolution, to match what can be realised in longer, free-breathing acquisitions.

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Single breath-hold EPI-based 3D Late Gadolinium Enhancement Imaging

Key Points

Abstract

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