What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Optimisation and Validation of Fetal Brain T1 Mapping under Breath-Hold at 1.5T: Utilising Look-Locker and MOLLI Methods

Key Points

Look-Locker method achieved the highest accuracy for T1 mapping in the fetal brain while minimizing acquisition time.
Sampling 12 TIs every 800ms resulted in low standard deviation across a range of expected T1s.
Validation was performed against inversion recovery spin-echo mapping, establishing reliability of the fast mapping methods.
The study emphasizes the potential for efficient T1 characterization in fetal imaging, aiding clinical applications.

Abstract

Motivation: Characterising T1 values in the fetal brain can aid in the optimisation of T1-weighted sequences, but literature at 1.5T is limited and most mapping methods are long and motion intolerant. Goal(s): Optimise T1 mapping methods for use in utero, limiting acquisition time to a maternal breath-hold. Approach: Compare various fast mapping methods and validate accuracy against inversion recovery spin-echo mapping in a test object. Results: A Look-Locker approach sampling 12 TIs every 800ms was the most accurate with relatively low standard deviation over the range of T1s expected in the fetal brain, while restricting acquisition time to one breath-hold per slice. Impact: Performing T1 mapping on a cohort of fetal participants will allow a more comprehensive dataset to be collected, enabling T1 contrast to be better optimised in fetal imaging and expanding on the T1 characterisation available in the literature.

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Cite This Study

Lowe et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d643 https://doi.org/https://doi.org/10.58530/2025/3795

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