Rapid Access to Difluoroalkyl Phosphinimide Heterocycles and the Preliminary Biological Activities toward Cathepsin D Active Site

Key Points

• The synthesis of 'CF2'-functionalized cyclic phosphinimides shows promising biological activity against cathepsin D.
• An efficient Ir-catalyzed multicomponent photoredox reaction enables the rapid access to these compounds.
• The study presents a new pathway for creating diverse phosphinimides with potential therapeutic applications.
• This method employs C-H activation to streamline the synthesis process, suggesting efficiency in pharmaceutical development.