ABSTRACT BACKGROUND AND PURPOSE: Gadolinium-based contrast agents (GBCAs) are essential in pediatric neuroimaging, enabling visualization of pathology that disrupts the blood–brain barrier. Gadopiclenol is a new macrocyclic GBCA with higher T1 relaxivity, permitting a 50% dose reduction while maintaining diagnostic quality. However, it is unknown whether this higher relaxivity alters background extra-axial vascular enhancement. We hypothesized that gadopiclenol, despite its lower dose, would increase background enhancement on post-contrast pediatric brain MRI compared to gadoterate meglumine (Gd-DOTA). MATERIALS AND METHODS: In this retrospective observational study, 302 contrast-enhanced brain MRI studies in patients aged 2–18 years were reviewed: 151 with gadopiclenol (0.05 mmol/kg) and 151 with Gd-DOTA (0.1 mmol/kg). Post-contrast sequences included 3D T1 spin echo (SE), 3D T1 gradient echo (SPGR), 2D T1 turbo spin echo (TSE), and 2D FLAIR. Two neuroradiologists established binary enhancement categories based on sulcal enhancement thresholds (high vs. low). One reader assigned scores for all studies; a second reader evaluated a subset for interobserver agreement. Logistic regression assessed the association between contrast agent and high enhancement, adjusting for age, sex, anesthesia, and scanner field strength. RESULTS: Gadopiclenol was independently associated with significantly greater odds of high extra-axial enhancement on all T1-weighted sequences: 3D T1 SE (OR = 10.2, p CONCLUSIONS: Gadopiclenol increases background extra-axial enhancement on T1-weighted post-contrast sequences in pediatric brain MRI, likely reflecting its higher relaxivity. Radiologists should be aware of this effect to avoid misinterpretation as leptomeningeal pathology. Post-contrast FLAIR remains unaffected and continues to serve as a reliable sequence for detecting true meningeal disease. ABBREVIATIONS: GBCA= gadolinium-based contrast agent; SE= spin echo; SPGR= spoiled gradient echo; TSE= turbo spin echo.
Valencia et al. (Sat,) studied this question.