In the quest for advanced materials that can effectively combat biofilm-associated infections while ensuring material integrity, graphene oxide coated-aluminum (AlGO) substrates have emerged as an innovative solution. Despite the well-documented antimicrobial capabilities of graphene oxide, its application at lower concentrations to preserve the structural and biological compatibility of metal alloys remains inadequately explored. This research addresses this gap by optimizing GO coatings at lower concentrations to achieve a delicate balance between antimicrobial efficacy and material biocompatibility. We explore the synergistic combination of electrochemically deposited GO at various concentrations (50, 100, 250, and 500 ug/mL) with PEDOT: PSS on AA1050 aluminum alloy (AlGO/P). This approach aims to create a robust coating that enhances corrosion resistance, biocompatibility, and the antifouling properties of AA1050 Al, towards biofilm-forming organisms such as Candida albicans, Staphylococcus aureus, and Escherichia coli. Current study identifies that concentrations, particularly 100 and 250 ug/mL of GO on AA1050 aluminum alloy exhibit potent biocidal activity, while preserving aforementioned material properties. Since Al is an infinitely recyclable, green material, this work offers a sustainable alternative to traditional antimicrobial surfaces. Further, this presents a contemporary strategy for surface modification of implantable biomedical devices, potentially reducing periprosthetic infection and extending device longevity; as well as for ex vivo material applications requiring strong antimicrobial performance.
Nasker et al. (Mon,) studied this question.
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