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Abstract Objective: This study investigates the relationship between the psychological state, sleep patterns, COVID-19 vaccine administration, and adverse pregnancy outcomes among pregnant women during the COVID-19 pandemic. Methods: A prospective cohort study was conducted from April 2022 to November 2022 at the First Affiliated Hospital of Sun Yat-sen University, including 260 pregnant women meeting the inclusion criteria in the obstetric department. The Depression Anxiety Stress Scales (DASS-21) was used to assess depression, anxiety, and stress; the Impact of Event Scale-Revised (IES-R) was utilized to evaluate psychological stress related to COVID-19, and the Pittsburgh Sleep Quality Index (PSQI) was employed to measure sleep quality. Participants were grouped based on their scores or vaccination status, and the incidence of adverse pregnancy outcomes was compared among different groups. Results: There was a statistically significant difference in the incidence of Postpartum Hemorrhage (PPH) among groups with varying degrees of depression (P 0.05). The comparison of COVID-19 vaccine administration showed no statistically significant differences in psychological status and adverse pregnancy outcomes (P > 0.05). Conclusion: COVID-19-related depression may increase the risk of PPH. COVID-19 vaccination has no impact on pregnant women's mental health and adverse pregnancy outcomes. So, it can be considered a measure to prevent COVID-19 infection.
Cai et al. (Wed,) studied this question.