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Histotripsy is an innovative non-invasive modality utilizing high-intensity focused ultrasound to induce mechanical tissue disruption via controlled cavitation. It represents a promising approach in oncology, offering a targeted alternative to conventional cancer therapies. The method relies on precise acoustic energy to create microbubbles that implode, causing cellular destruction within the targeted area while sparing surrounding tissues. In this review, we have explored the foundational principles underlying histotripsy, outlining how it leverages the physics of sound and cavitation to achieve precise tissue disruption. We have delved into the specific mechanisms by which histotripsy induces cell death. This review provides an overview of the current clinical applications of histotripsy in the treatment of various cancers, highlighting its benefits and the clinical outcomes reported thus far. Further, the review examines the breadth of ongoing research related to histotripsy. Looking to the future, the review discusses the promising implications of histotripsy for revolutionizing cancer care.
Parashar et al. (Fri,) studied this question.