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Abstract In this single center retrospective study, we aimed to observe the characteristics of resting potentials between RPE and photoreceptors in RMD patients, based on electrooculography. Seven patients with diffuse RMD diagnosed using infrared fundus photography and optical coherence tomography (OCT) were consecutively reviewed. All 7 patients (14 eyes) underwent routine ophthalmic examinations and were examined by OCT and Electrooculography (EOG). The EOG recordings of the 14 eyes revealed that dark adaptation took 7.21 ± 1.75 minutes to achieve dark trough, whereas light adaptation took 15.79 ± 2.70 minutes from light rise to the light peak. Furthermore, the amplitude of dark trough potential was 262.0–962.1 µV, whereas that of light peak potential was between 373.8 µV and 1.8 mV. In addition, the LP:DT ratio of the 14 eyes observed in this preliminary study was 1.63 ± 0.22, ranged between 1.18 and 1.97, which was lower than 2.35, but was not significantly lower than the lower limit of 1.7 (t = -1.12, P = 0.28). In conclusion, Some EOG parameters of RMD patients are different from normal reference ranges, bioelectric activity between RPE and photoreceptors in patients with RMD may be affected by SDD or RPE abnormalities.
Ren et al. (Mon,) studied this question.
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