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Background: Acute Lung Injury (ALI) is a high-fatality respiratory disease, and the development of new therapeutic agents is ongoing. The rhizome of Ligusticum chuanxiong Hort. ( L. chuanxiong ) has been prescribed for the therapy of ALI in traditional Chinese medicine. Objective: The purpose of this article is to explore the effective ingredients, targets, and mechanisms in the treatment of L. chuanxiong on ALI. Methods: The active ingredients of L. chuanxiong were obtained in the TCMSP, and their potential targets and ALI targets were predicted in TCMSP, Swiss target prediction, and Genecards database. A PPI network was constructed in the string online platform, and KEGG and GO enrichment analysis were conducted in the metascape online platform. Phytochemical investigation of the rhizome of L. chuanxiong was performed with chemical separation methods and structural elucidation techniques, and their pharmacological effects were evaluated using LPS-induced mouse ALI model and cell-based assays. Results: Network pharmacology analyses indicated that the treatment of L. chuanxiong on ALI was associated with its anti-inflammatory effect. The key genes mainly include TNF, STAT3, EGFR, AKT1, BCL2, CASP3, and SRC, and the active compounds are its signature component, phthalides. Phytochemical investigation led to the elucidation of 23 phthalides, which demonstrated an anti-inflammatory effect in vitro and in vivo . Of which, chuanxiongdiolide A, levistilide A, butylphthalide, and senkyunolide A were indeed effective in mitigating ALI in an LPS-induced mouse model. Conclusion: The combined network pharmacological, phytochemical, and pharmacological investiagtions revealed that the therapeutical effect of L. chuanxiong against ALI was associated with inhibition of the inflammatory response by phthalides.
Xu et al. (Wed,) studied this question.
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